小胶质细胞通过T细胞募集来指挥衰老过程中白质退化的交响乐

IF 20 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-05-22 DOI:10.1038/s41593-025-01929-y

Jonathan K. Monteiro, Veronique E. Miron

{"title":"小胶质细胞通过T细胞募集来指挥衰老过程中白质退化的交响乐","authors":"Jonathan K. Monteiro, Veronique E. Miron","doi":"10.1038/s41593-025-01929-y","DOIUrl":null,"url":null,"abstract":"Aging induces pathological changes in central nervous system (CNS) myelin, which in turn induce microglia dysregulation. What is the consequence of this microglial response on white matter pathology in aging? Groh et al. show that a maladaptive white matter-associated microglia state that emerges in aging recruits peripheral T cells to the CNS, which leads to degeneration of myelinated axons and loss of function.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"15 1","pages":""},"PeriodicalIF":20.0000,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment\",\"authors\":\"Jonathan K. Monteiro, Veronique E. Miron\",\"doi\":\"10.1038/s41593-025-01929-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aging induces pathological changes in central nervous system (CNS) myelin, which in turn induce microglia dysregulation. What is the consequence of this microglial response on white matter pathology in aging? Groh et al. show that a maladaptive white matter-associated microglia state that emerges in aging recruits peripheral T cells to the CNS, which leads to degeneration of myelinated axons and loss of function.\",\"PeriodicalId\":19076,\"journal\":{\"name\":\"Nature neuroscience\",\"volume\":\"15 1\",\"pages\":\"\"},\"PeriodicalIF\":20.0000,\"publicationDate\":\"2025-05-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41593-025-01929-y\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41593-025-01929-y","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

衰老引起中枢神经系统髓磷脂的病理改变，进而引起小胶质细胞失调。这种小胶质细胞对衰老过程中白质病理的反应有什么影响？Groh等人的研究表明，衰老过程中出现的一种与白质相关的小胶质细胞不适应状态将外周T细胞招募到中枢神经系统，从而导致髓鞘轴突退化和功能丧失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment

查看原文本刊更多论文

Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment

Aging induces pathological changes in central nervous system (CNS) myelin, which in turn induce microglia dysregulation. What is the consequence of this microglial response on white matter pathology in aging? Groh et al. show that a maladaptive white matter-associated microglia state that emerges in aging recruits peripheral T cells to the CNS, which leads to degeneration of myelinated axons and loss of function.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.