在单个选择轮中对高亲和性适配体进行排序

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2025-05-22 DOI:10.1038/s41589-025-01917-0

Gayathri Kasirajan, William H. Thiel

引用次数: 0

摘要

适配体是一种短的单链DNA或RNA分子，能够以高特异性和亲和力结合靶分子，作为治疗剂和诊断工具具有相当大的潜力。一种新的方法，UltraSELEX，从一轮高通量筛选中确定最佳序列。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Sorting high-affinity aptamers in a single selection round

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Sorting high-affinity aptamers in a single selection round

Aptamers are short, single-stranded DNA or RNA molecules that can bind target molecules with high specificity and affinity and have considerable potential as therapeutic agents and diagnostic tools. A new method, UltraSELEX, identifies optimal sequences from a single round of high-throughput screening.

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.