血管内皮功能障碍对冠状动脉疾病的影响:一项系统综述。

Q4 Medicine
West African journal of medicine Pub Date : 2024-12-30
A Ismail, K Isyaku, M U Sani
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引用次数: 0

摘要

背景:冠状动脉疾病(CAD)是一个主要的全球健康问题,特别是在低收入和中等收入国家(LMICs)。血管内皮功能障碍在冠心病的发展中起关键作用。目的:本系统综述评估了内皮功能障碍在冠心病进展中的作用的现有文献。方法:审查方案在PROSPERO注册(CRD42024539722)。综合文献检索确定了70篇相关文章。在删除15个重复项后,根据标题和摘要筛选了55篇研究,排除了35篇不符合纳入标准的文章。最后,纳入了15项研究,共涉及3,673名受试者(单个研究样本量从14到936,中位数为106)。结果:15项研究(3,673名受试者,1998-2023年)包括9项横断面研究、5项队列研究和1项回顾性研究。通过血管造影(10项研究)或其他方法(如应激心电图和心脏酶)确诊CAD。使用FMD(8项研究)和其他技术评估内皮功能障碍。五项研究将内皮功能障碍与冠心病严重程度联系起来,而队列研究表明,即使血管造影正常,其在预测不良心血管事件中的作用。结论:本系统综述强调了内皮功能在冠心病中的重要作用,强调了内皮功能在冠心病风险评估、早期发现和指导治疗决策中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Global Insights into the Impact of Endothelial Dysfunction on Coronary Artery Disease: A Systematic Review.

Background: Coronary artery disease (CAD) is a major global health issue, especially in low- and middle-income countries (LMICs). The dysfunction of the vascular endothelium plays a critical role in CAD progression.

Objectives: This systematic review evaluated existing literature on the role of endothelial dysfunction in the progression of CAD.

Methods: The review protocol was registered with PROSPERO (CRD42024539722). A comprehensive literature search identified 70 relevant articles. After removing 15 duplicates, 55 studies were screened based on title and abstract, leading to the exclusion of 35 articles that did not meet the inclusion criteria. Finally, 15 studies, encompassing a total of 3,673 subjects (with individual study sample sizes ranging from 14 to 936, and a median of 106), were included in the review.

Results: The 15 studies (3,673 subjects, 1998-2023) included 9 cross-sectional, 5 cohort, and 1 retrospective study. CAD diagnosis was confirmed via angiography (10 studies) or other methods like stress ECG and cardiac enzymes. Endothelial dysfunction was assessed using FMD (8 studies) and other techniques. Five studies linked endothelial dysfunction to CAD severity, while cohort studies suggested its role in predicting adverse cardiovascular events, even with normal angiograms.

Conclusion: This systematic review highlights the crucial role of endothelial function in CAD and emphasizes the importance of endothelial function in risk assessment, early detection, and guiding treatment decisions in CAD.

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来源期刊
West African journal of medicine
West African journal of medicine Medicine-Medicine (all)
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