化疗和放疗引起的口腔黏膜炎:代谢组学在治疗中的潜力。

Q4 Medicine
West African journal of medicine Pub Date : 2024-12-30
U Otakhoigbogie, N E Onyia, S A Uzodufa
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引用次数: 0

摘要

背景:口腔黏膜炎(OM)是头颈部癌症患者接受化疗和/或放疗时常见的衰弱性并发症。OM的发病机制涉及癌症治疗引发的炎症、免疫和细胞损伤途径的多方面相互作用。OM的发病机制可分为五个重叠的阶段:起始、信号传导、信号放大、溃疡和愈合。代谢组学:对参与细胞过程的小分子代谢物进行大规模研究,已成为理解口腔黏膜炎(OM)等复杂疾病的有力工具。这篇详细的文献综述综合了目前关于OM代谢组学的知识,重点是其在理解发病机制、识别预测性生物标志物和探索治疗策略方面的应用。结论:代谢组学领域通过提供与口腔黏膜炎相关的代谢改变的动态快照,彻底改变了对口腔黏膜炎的理解。它是识别早期诊断、监测和优化治疗的潜在生物标志物的有力工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemotherapy and Radiotherapy-Induced Oral Mucositis: The Potentials of Metabolomics in the Management.

Background: Oral mucositis (OM) is a debilitating complication commonly experienced by patients undergoing chemotherapy and/or radiotherapy for head and neck cancers. The pathogenesis of OM involves multifaceted interplay of inflammatory, immune, and cellular damage pathways triggered by cancer therapy. The pathogenesis of OM can be delineated into five overlapping phases: initiation, signaling, signal amplification, ulceration, and healing.

Metabolomics: The large-scale study of metabolites which are small molecules involved in cellular processes, has emerged as a powerful tool in understanding complex conditions like oral mucositis (OM). This detailed literature review synthesizes current knowledge on the metabolomics of OM, with a focus on its application to understanding the pathogenesis, identifying predictive biomarkers, and exploring therapeutic strategies.

Conclusion: The field of metabolomics has revolutionized the understanding of oral mucositis by providing a dynamic snapshot of the metabolic alterations associated with it. It is a powerful tool for identifying potential biomarkers for early diagnosis, monitoring, and treatment optimization.

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来源期刊
West African journal of medicine
West African journal of medicine Medicine-Medicine (all)
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