Sri Vidhya, Divya Sundaresh, Christy Bobby, Aditya Goyal, Nikhita Jacob, Denny John
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引用次数: 0
摘要
目的：研究人类弱视临床亚群中抑制性暗点与视力的关系，探讨不同的弱视致病因素是否会导致不同的抑制性暗点特征及其与视力的关系。弱视是一种神经发育障碍，由于视觉通路的生理改变而损害单眼或双眼的视觉灵敏度、立体灵敏度和对比灵敏度。许多研究已经检验了弱视和抑制之间的关系。然而，在弱视中，抑制大小、深度和视力之间的关系尚不清楚。纳入标准：本综述将包括随机对照试验、队列研究、病例对照研究和横断面研究，参与者为任何年龄或性别，诊断为弱视，并具有视力（LogMAR或Snellen分数）、抑制大小（视角程度）和抑制深度（两视目标的对比差异）的结果测量。方法：本综述将遵循JBI方法对病因和风险进行系统评价。将检索学术和非学术数据库以及灰色文献，包括MEDLINE （Ovid）、Embase （Ovid）、Cochrane Central Register of Controlled Trials （Central）、Web of Science Core Collection、ProQuest Health and Medical Collection和谷歌Scholar。纳入研究的标题和摘要以及随后的全文将由2名独立审稿人进行筛选。关键评估将使用JBI检查清单进行。在可能的情况下，这些研究将使用随机效应荟萃分析进行汇总。如果统计汇集不可能，调查结果将以叙述形式提出，包括表格和数字。证据的确定性将使用建议、评估、发展和评估分级（GRADE）方法进行评估。审核注册：PROSPERO CRD42023479043。
Association between suppression scotoma and visual acuity in clinical subgroups of amblyopia: a systematic review protocol.
Objective: This review will examine the association between suppression scotoma and visual acuity in clinical subgroups of amblyopia in humans to determine whether distinct causal factors of amblyopia lead to different suppression characteristics and their association with visual acuity.
Introduction: Amblyopia is a neurodevelopmental disorder that impairs visual acuity, stereo acuity, and contrast sensitivity in 1 or both eyes due to physiological alterations in the visual pathways. Numerous studies have examined the association between amblyopia and suppression. However, the relationship between suppression size, depth, and visual acuity in amblyopia remains unclear.
Inclusion criteria: This review will include randomized controlled trials, cohort studies, case-control studies, and cross-sectional studies, with participants of any age or gender, diagnosed with amblyopia and with outcome measures of visual acuity (in LogMAR or Snellen's fraction), suppression size (degree of visual angle), and suppression depth (contrast difference in dichoptic targets).
Methods: This review will follow the JBI methodology for systematic reviews of etiology and risk. Academic and non-academic databases and gray literature will be searched, including MEDLINE (Ovid), Embase (Ovid), Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science Core Collection, ProQuest Health and Medical Collection, and Google Scholar. Titles and abstracts, and later, full texts of included studies will be screened by 2 independent reviewers. Critical appraisal will be conducted using JBI checklists. Where possible, the studies will be pooled using random effects meta-analysis. If statistical pooling is not possible, the findings will be presented in narrative format, including tables and figures. Certainty of the evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.
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