疟疾疫苗RTS，S/AS01诱导小鼠抗体介导保护的表位特异性

IF 6.9 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-05-20 DOI:10.1038/s41541-025-01162-5

Yevel Flores-Garcia, Berenice Salgado-Jimenez, Minah Park, Shamika Mathis-Torres, Emily Locke, Randall S MacGill, Re'em Moskovitz, Ian A Wilson, Fidel Zavala

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引用次数: 0

摘要

由疟疾疫苗RTS，S/AS01诱导的抗体可中和表达恶性疟原虫CSP （PfCSP）的转基因孢子子的传染性。这些抗体识别该抗原的连接、次要重复、中心重复和c项区域。利用表达PfCSP限制性抗原部分的转基因孢子体，在体内鉴定了介导小鼠保护的抗体表位特异性。在这个模型中，我们发现保护主要是由针对中心重复序列的抗体介导的。

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Epitope specificity of antibody-mediated protection induced in mice by the malaria vaccine RTS,S/AS01.

Antibodies induced by the malaria vaccine RTS,S/AS01 neutralize infectivity of transgenic sporozoites expressing Plasmodium falciparum CSP (PfCSP). These antibodies recognize the junctional, minor repeats, central repeats, and C-term regions of this antigen. The epitope specificity of antibodies mediating protection in mice was characterized in vivo using transgenic sporozoites expressing restricted antigenic portions of PfCSP. In this model, we found protection is mediated mostly by antibodies specific for the central repeats.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.