{"title":"皮脂分泌:肥胖发病机制中的缺失链。","authors":"Jalal Hejazi","doi":"10.1093/nutrit/nuaf064","DOIUrl":null,"url":null,"abstract":"<p><p>Every day, a significant amount of fat is excreted through the skin in the form of sebum. However, this significant calorie loss, which may amount to up to 500 kcal/day in individuals with greasy skin, has often been disregarded in obesity studies. The most important theoretical models of the pathogenesis of obesity, the Energy Balance Model and the Carbohydrate-Insulin Model, need to be re-evaluated taking this into account, and \"energy loss through the skin\" should be included in the energy-balance equation. This overlooked pathway might partially explain discrepancies in energy balance measurements. Factors affecting sebum production may also affect weight; however, this requires further research.</p>","PeriodicalId":19469,"journal":{"name":"Nutrition reviews","volume":" ","pages":""},"PeriodicalIF":5.9000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sebum Secretion: The Missing Chain in the Pathogenesis of Obesity.\",\"authors\":\"Jalal Hejazi\",\"doi\":\"10.1093/nutrit/nuaf064\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Every day, a significant amount of fat is excreted through the skin in the form of sebum. However, this significant calorie loss, which may amount to up to 500 kcal/day in individuals with greasy skin, has often been disregarded in obesity studies. The most important theoretical models of the pathogenesis of obesity, the Energy Balance Model and the Carbohydrate-Insulin Model, need to be re-evaluated taking this into account, and \\\"energy loss through the skin\\\" should be included in the energy-balance equation. This overlooked pathway might partially explain discrepancies in energy balance measurements. Factors affecting sebum production may also affect weight; however, this requires further research.</p>\",\"PeriodicalId\":19469,\"journal\":{\"name\":\"Nutrition reviews\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2025-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/nutrit/nuaf064\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/nutrit/nuaf064","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Sebum Secretion: The Missing Chain in the Pathogenesis of Obesity.
Every day, a significant amount of fat is excreted through the skin in the form of sebum. However, this significant calorie loss, which may amount to up to 500 kcal/day in individuals with greasy skin, has often been disregarded in obesity studies. The most important theoretical models of the pathogenesis of obesity, the Energy Balance Model and the Carbohydrate-Insulin Model, need to be re-evaluated taking this into account, and "energy loss through the skin" should be included in the energy-balance equation. This overlooked pathway might partially explain discrepancies in energy balance measurements. Factors affecting sebum production may also affect weight; however, this requires further research.
期刊介绍:
Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.