激素治疗和口服避孕药对膝骨关节炎风险的影响：一项前瞻性队列研究。

IF 2.8 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Menopause: The Journal of The North American Menopause Society Pub Date : 2025-05-20 DOI:10.1097/GME.0000000000002560

Junjie Wang, Xiaoyue Zhang, Liru Ge, Xing Xing, Xusheng Cheng, Jianqiao Wang, Jingyi Yin, Xianzhe Zhu, Guoqi Cai

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引用次数: 0

摘要

目的：探讨激素治疗（HT）和口服避孕药（OC）与膝骨关节炎（KOA）发病风险的关系。方法：使用来自UK Biobank的数据，我们纳入了211,345名女性（平均56.5岁），这些女性无KOA，并在基线时自我报告使用HT和OC的数据。结果是在随访期间发生意外KOA。使用Cox回归模型评估HT和OC使用状态（从未、曾经、现在）和持续时间与KOA风险的关系。我们还评估了特定外源性性激素与KOA风险之间的关系。结果：在中位随访13.6年期间，14878名（7.0%）女性发生KOA。与从未使用过羟色胺的女性相比，曾经使用羟色胺和现在使用羟色胺的女性患KOA的风险都增加了[以前：危险比(HR)=1.25, 95% CI: 1.20-1.31；电流：HR=1.46, 95% CI: 1.35-1.58；结论：中老年妇女使用激素的时间与KOA风险之间存在剂量反应关系。在60岁以下的女性中，使用酒精的历史可能会增加KOA的风险。

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Hormone therapy and oral contraceptives in the risk of knee osteoarthritis: a prospective cohort study.

Objective: To evaluate the association of hormone therapy (HT) and oral contraceptives (OC) with the risk of knee osteoarthritis (KOA).

Methods: Using data from the UK Biobank, we included 211,345 women (mean 56.5 y) who were free of KOA and had self-reported data on the use of HT and OC at baseline. The outcome was an incident KOA during the follow-up. Cox regression models were used to evaluate the association of the status (never, former, current) and duration of HT and OC use with the risk of KOA. We also assessed the association between specific exogenous sex hormones and the risk of KOA.

Results: During a median follow-up of 13.6 years, 14,878 (7.0%) women developed KOA. Compared with women who had never used HT, both former and current users had an increased risk of KOA [former: hazard ratio (HR)=1.25, 95% CI: 1.20-1.31; current: HR=1.46, 95% CI: 1.35-1.58; Ptrend<0.001). There was a dose-responsive association between the duration of HT use and the risk of KOA (HR=1.20-1.43, Ptrend<0.001). Former use of OC increased KOA risk only in women <60 years (HR=1.15, 95% CI: 1.04-1.27). In addition, both estrogen and progestogen and their combination were associated with an increased risk of KOA (HR=1.33-1.47).

Conclusions: There is a dose-responsive association between the duration of HT use and the risk of KOA among middle-aged and older women. History of OC use may increase the risk of KOA in women younger than 60 years.

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来源期刊

Menopause: The Journal of The North American Menopause Society 医学-妇产科学

CiteScore

5.40

自引率

7.40%

发文量

330

审稿时长

3-8 weeks

期刊介绍： Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.