牙龈卟啉单胞菌-脂多糖和淀粉样蛋白-β：损害记忆的危险联系？

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-07-01 DOI:10.1177/13872877251343317

Sim K Singhrao

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引用次数: 0

摘要

阿尔茨海默病的特点是记忆力下降，大脑中存在不溶性淀粉样蛋白-β (Aβ)斑块和神经原纤维缠结。Gui等人1研究了低水平牙龈卟啉单胞菌脂多糖（P. gingivalis-LPS）和可溶性Aβ对突触蛋白、突触素1 （SYN1）和突触后密度蛋白-95 （PSD-95）的影响。他们的研究显示，牙龈假单胞杆菌- lps和Aβ处理的小胶质细胞（MG6）中促炎细胞因子的产生增加，而暴露于MG6条件培养基的神经元细胞N2a显示SYN1和PSD-95的缺失。这表明过度的神经炎症可能导致突触蛋白和记忆丧失，为牙周炎中牙龈卟啉卟啉-脂多糖介导的炎症途径提供了机制见解。

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Porphyromonas gingivalis-lipopolysaccharide and amyloid-β: A dangerous liaison for impairing memory?

Alzheimer's disease is characterized by declining memory and the presence of insoluble amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. Gui et al.¹ studied the effects of low levels of Porphyromonas gingivalis-lipopolysaccharide (P. gingivalis-LPS) and soluble Aβ on synaptic proteins, synapsin1 (SYN1) and post-synaptic density protein-95 (PSD-95). Their study revealed increased proinflammatory cytokine production in microglial cells (MG6) treated with P. gingivalis-LPS and Aβ, while neuronal cells, N2a, exposed to MG6-conditioned medium showed SYN1 and PSD-95 loss. This suggests that excessive neuroinflammation may contribute to synaptic protein and memory loss, offering mechanistic insights into P. gingivalis-LPS-mediated inflammatory pathways in periodontitis.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.