暴露于生物质燃烧产生的季节性PM2.5增加了健康围绝经期妇女维生素D缺乏症的风险。

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Mattabhorn Phimphilai, Sridanai Watthanawongkeeree, Worapaka Manosroi
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引用次数: 0

摘要

目的:东南亚面临着生物质燃烧造成的季节性空气污染问题。关于维生素D缺乏和季节性空气污染的数据有限。因此,本研究旨在确定季节性空气污染物对维生素D缺乏的影响以及雾霾期间维生素D缺乏的预测因素。方法:本前瞻性队列研究纳入77名围绝经期妇女。所有参与者分别在污染高峰和低污染时期登记并随访。测定血清25-羟基维生素D (25(OH)D)。24小时直径小于2.5µm的颗粒物(PM2.5)数据来自泰国污染控制部门的数据库。结果:24 h PM2.5较高(46.9±4.7µg/m3 vs. 11.2±5.1µg/m3),污染物峰值期间的PM2.5是维生素D缺乏的独立预测因子。其阈值为20µg/m3,预测维生素D缺乏症的敏感性、特异性和准确性分别为75.0%、85.7%和78.0%。结论:季节性空气污染物增加维生素D缺乏的风险。24 h环境PM2.5浓度为20µg/m3,对维生素D缺乏症具有较高的诊断效能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exposure to seasonal PM2.5 derived from biomass burning increased the risk of vitamin D deficiency in healthy perimenopausal women.

Objective: Southeast Asia faces problems with seasonal air pollution from biomass burning. Data regarding vitamin D deficiency and seasonal air pollution is limited. Therefore, this study aimed to determine the effects of seasonal air pollutants on vitamin D deficiency and the predictors of vitamin D deficiency during haze periods.

Methods: This prospective cohort study included 77 peri-menopausal women. All participants were enrolled and followed at the peak and low pollutant periods, respectively. Serum 25-hydroxyvitamin D (25(OH)D) was measured at both points. Data regarding 24 h particulate matter with a diameter less than 2.5 µm (PM2.5) was obtained from the database of the Pollution Control Department of Thailand.

Results: The ambient 24 h PM2.5 was higher (46.9 ± 4.7 µg/m3 vs. 11.2 ± 5.1 µg/m3, P < 0.001) at the peak pollutant period. In contrast, serum 25(OH)D level was 18.8% lower, and the incidence of vitamin D deficiency was 45.4% higher at the peak pollutant period compared to those at the low pollutant period. Seasonal air pollutants were associated with an increased risk of vitamin D deficiency by 3.5 folds [OR 3.5 (95% CI 1.1-14.6)]. The ambient 24 h PM2.5 during the peak pollutant periods was an independent predictor of vitamin D deficiency. Its threshold of 20 µg/m3 demonstrated sensitivity, specificity, and accuracy of 75.0%, 85.7%, and 78.0%, respectively, to predict the occurrence of vitamin D deficiency.

Conclusion: Seasonal air pollutants increase the risk of vitamin D deficiency. The ambient 24 h PM2.5 at 20 µg/m3 demonstrated high diagnostic performance for vitamin D deficiency.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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