{"title":"妊娠前和妊娠期间暴露于细颗粒物及其化学成分的环境空气污染与足月小于胎龄风险的关系:一项回顾性队列研究","authors":"Tingrong Wang, Hanping Ma, Rui Li, Donghua Li, Tianshan Shi, Zhenjuan Li, Zixuan Zou, Xiaowei Ren","doi":"10.1007/s00420-025-02141-y","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>In the current study, we explored the associations between exposure to fine particulate matter (PM<sub>2.5</sub>) constituents and full-term small for gestational age (SGA) in different periods.</p><p><strong>Methods: </strong>We included 155,897 participants, and matched the exposure concentrations of PM<sub>2.5</sub> and its constituents [sulfate (SO<sub>4</sub><sup>2-</sup>), nitrate (NO<sub>3</sub><sup>-</sup>), ammonium (NH<sub>4</sub><sup>+</sup>), organic matter (OM), and black carbon (BC)] according to participants' geographical location. To explore the associations of prenatal exposure to PM<sub>2.5</sub> and its constituents with the risk of full-term SGA, we used logistic regression, restricted cubic spline regression (RCS) and quartile g-computation (QGCOMP).</p><p><strong>Results: </strong>We found that individual exposure to PM<sub>2.5</sub> and its constituents was positively associated with the risk of full-term SGA (P < 0.05), whether in the year before pregnancy or the entire pregnancy. These associations were more pronounced in the second trimester. We found that the risk of full-term SGA was positively and linearly related to the concentrations of PM<sub>2.5</sub> and its constituents (P<sub>overall</sub> < 0.05, P<sub>nonlinear</sub> > 0.05). The associations of PM<sub>2.5</sub> and its constituents with full-term SGA were stronger in multiparous mothers. Moreover, full-term SGA was associated with exposure to mixtures of SO<sub>4</sub><sup>2-</sup>, NO<sub>3</sub><sup>-</sup>, NH<sub>4</sub><sup>+</sup>, OM, and BC before pregnancy and in the second and third trimester. Among these, BC was positively associated with full-term SGA at each of the aforementioned stages.</p><p><strong>Conclusions: </strong>The risk of full-term SGA was positively and linearly related to concentrations of PM<sub>2.5</sub> and its constituents, and these associations were more pronounced in the second trimester. BC was the most hazardous constituent of PM<sub>2.5</sub> that was associated with full-term SGA.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Associations of ambient air pollution exposure to fine particulate matter and its chemical constituents before and during pregnancy with the risk of full-term small for gestational age: a retrospective cohort study.\",\"authors\":\"Tingrong Wang, Hanping Ma, Rui Li, Donghua Li, Tianshan Shi, Zhenjuan Li, Zixuan Zou, Xiaowei Ren\",\"doi\":\"10.1007/s00420-025-02141-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>In the current study, we explored the associations between exposure to fine particulate matter (PM<sub>2.5</sub>) constituents and full-term small for gestational age (SGA) in different periods.</p><p><strong>Methods: </strong>We included 155,897 participants, and matched the exposure concentrations of PM<sub>2.5</sub> and its constituents [sulfate (SO<sub>4</sub><sup>2-</sup>), nitrate (NO<sub>3</sub><sup>-</sup>), ammonium (NH<sub>4</sub><sup>+</sup>), organic matter (OM), and black carbon (BC)] according to participants' geographical location. To explore the associations of prenatal exposure to PM<sub>2.5</sub> and its constituents with the risk of full-term SGA, we used logistic regression, restricted cubic spline regression (RCS) and quartile g-computation (QGCOMP).</p><p><strong>Results: </strong>We found that individual exposure to PM<sub>2.5</sub> and its constituents was positively associated with the risk of full-term SGA (P < 0.05), whether in the year before pregnancy or the entire pregnancy. These associations were more pronounced in the second trimester. We found that the risk of full-term SGA was positively and linearly related to the concentrations of PM<sub>2.5</sub> and its constituents (P<sub>overall</sub> < 0.05, P<sub>nonlinear</sub> > 0.05). The associations of PM<sub>2.5</sub> and its constituents with full-term SGA were stronger in multiparous mothers. Moreover, full-term SGA was associated with exposure to mixtures of SO<sub>4</sub><sup>2-</sup>, NO<sub>3</sub><sup>-</sup>, NH<sub>4</sub><sup>+</sup>, OM, and BC before pregnancy and in the second and third trimester. Among these, BC was positively associated with full-term SGA at each of the aforementioned stages.</p><p><strong>Conclusions: </strong>The risk of full-term SGA was positively and linearly related to concentrations of PM<sub>2.5</sub> and its constituents, and these associations were more pronounced in the second trimester. BC was the most hazardous constituent of PM<sub>2.5</sub> that was associated with full-term SGA.</p>\",\"PeriodicalId\":13761,\"journal\":{\"name\":\"International Archives of Occupational and Environmental Health\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Archives of Occupational and Environmental Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00420-025-02141-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Archives of Occupational and Environmental Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00420-025-02141-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Associations of ambient air pollution exposure to fine particulate matter and its chemical constituents before and during pregnancy with the risk of full-term small for gestational age: a retrospective cohort study.
Objective: In the current study, we explored the associations between exposure to fine particulate matter (PM2.5) constituents and full-term small for gestational age (SGA) in different periods.
Methods: We included 155,897 participants, and matched the exposure concentrations of PM2.5 and its constituents [sulfate (SO42-), nitrate (NO3-), ammonium (NH4+), organic matter (OM), and black carbon (BC)] according to participants' geographical location. To explore the associations of prenatal exposure to PM2.5 and its constituents with the risk of full-term SGA, we used logistic regression, restricted cubic spline regression (RCS) and quartile g-computation (QGCOMP).
Results: We found that individual exposure to PM2.5 and its constituents was positively associated with the risk of full-term SGA (P < 0.05), whether in the year before pregnancy or the entire pregnancy. These associations were more pronounced in the second trimester. We found that the risk of full-term SGA was positively and linearly related to the concentrations of PM2.5 and its constituents (Poverall < 0.05, Pnonlinear > 0.05). The associations of PM2.5 and its constituents with full-term SGA were stronger in multiparous mothers. Moreover, full-term SGA was associated with exposure to mixtures of SO42-, NO3-, NH4+, OM, and BC before pregnancy and in the second and third trimester. Among these, BC was positively associated with full-term SGA at each of the aforementioned stages.
Conclusions: The risk of full-term SGA was positively and linearly related to concentrations of PM2.5 and its constituents, and these associations were more pronounced in the second trimester. BC was the most hazardous constituent of PM2.5 that was associated with full-term SGA.
期刊介绍:
International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors.
In addition, all papers should be based on present-day standards and relate to:
-Clinical and epidemiological studies on morbidity and mortality
-Clinical epidemiological studies on the parameters relevant to the estimation of health risks
-Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects.
-Methods for studying the topics mentioned above.