妊娠前和妊娠期间暴露于细颗粒物及其化学成分的环境空气污染与足月小于胎龄风险的关系:一项回顾性队列研究

IF 2.6 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Tingrong Wang, Hanping Ma, Rui Li, Donghua Li, Tianshan Shi, Zhenjuan Li, Zixuan Zou, Xiaowei Ren
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引用次数: 0

摘要

目的:在本研究中,我们探讨细颗粒物(PM2.5)成分暴露与不同时期足月小胎龄(SGA)之间的关系。方法:纳入155,897名参与者,根据参与者的地理位置匹配PM2.5及其组分[硫酸盐(SO42-)、硝酸盐(NO3-)、铵态氮(NH4+)、有机质(OM)和黑碳(BC)]的暴露浓度。为了探讨产前暴露于PM2.5及其成分与足月SGA风险的关系,我们使用了逻辑回归、限制三次样条回归(RCS)和四分位数g计算(QGCOMP)。结果:我们发现个体暴露于PM2.5及其成分与足月SGA风险呈正相关(p2.5及其成分)(powall非线性> 0.05)。PM2.5及其成分与足月SGA的相关性在多产母亲中更强。此外,足月SGA与妊娠前、妊娠中期和妊娠晚期暴露于SO42-、NO3-、NH4+、OM和BC的混合物有关。其中,在上述每个阶段,BC与足月SGA呈正相关。结论:足月SGA风险与PM2.5及其成分浓度呈线性正相关,且这种相关性在妊娠中期更为明显。BC是PM2.5中与足月SGA相关的最危险成分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of ambient air pollution exposure to fine particulate matter and its chemical constituents before and during pregnancy with the risk of full-term small for gestational age: a retrospective cohort study.

Objective: In the current study, we explored the associations between exposure to fine particulate matter (PM2.5) constituents and full-term small for gestational age (SGA) in different periods.

Methods: We included 155,897 participants, and matched the exposure concentrations of PM2.5 and its constituents [sulfate (SO42-), nitrate (NO3-), ammonium (NH4+), organic matter (OM), and black carbon (BC)] according to participants' geographical location. To explore the associations of prenatal exposure to PM2.5 and its constituents with the risk of full-term SGA, we used logistic regression, restricted cubic spline regression (RCS) and quartile g-computation (QGCOMP).

Results: We found that individual exposure to PM2.5 and its constituents was positively associated with the risk of full-term SGA (P < 0.05), whether in the year before pregnancy or the entire pregnancy. These associations were more pronounced in the second trimester. We found that the risk of full-term SGA was positively and linearly related to the concentrations of PM2.5 and its constituents (Poverall < 0.05, Pnonlinear > 0.05). The associations of PM2.5 and its constituents with full-term SGA were stronger in multiparous mothers. Moreover, full-term SGA was associated with exposure to mixtures of SO42-, NO3-, NH4+, OM, and BC before pregnancy and in the second and third trimester. Among these, BC was positively associated with full-term SGA at each of the aforementioned stages.

Conclusions: The risk of full-term SGA was positively and linearly related to concentrations of PM2.5 and its constituents, and these associations were more pronounced in the second trimester. BC was the most hazardous constituent of PM2.5 that was associated with full-term SGA.

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来源期刊
International Archives of Occupational and Environmental Health
International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
5.60
自引率
6.70%
发文量
127
审稿时长
3 months
期刊介绍: International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.
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