血清Mg2+浓度对心力衰竭合并2型糖尿病患者的预后价值：一项回顾性队列研究

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2025-05-21 DOI:10.1007/s12020-025-04282-z

Yangyang Jiang, Jingshu Zhang, Zhichao Jiang, Xiaoyu Liu, Lixin Wang

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引用次数: 0

摘要

背景：流行病学研究发现血清Mg2+浓度与2型糖尿病（T2DM）患者发生心力衰竭（HF）和心房颤动（AF）的风险呈负相关。血清Mg2+浓度与HF和T2DM患者预后的相关性尚不清楚。目的：在一项HF和T2DM患者的回顾性队列研究中，评估血清Mg2+浓度与心血管事件发生率的关系。方法：本研究纳入2018年7月至2021年12月在天津中医药大学第一教学医院诊断为HF和T2DM的患者。主要终点是心血管死亡或心衰再住院。结果：本研究纳入了216例HF合并T2DM患者。根据血清Mg2+水平将患者分为T1组（血清Mg2+水平≤0.8 mmol/L）、T2组（血清Mg2+水平≤0.89 mmol/L）、T3组（血清Mg2+水平≥0.9 mmol/L）。Kaplan-Meier分析显示，三组患者的主要终点发生率均显著升高(P 2+水平被认为是T2DM与HF共存且预后不良的保护因素。结论：我们的研究结果表明，血清Mg2+浓度升高可能改善HF和T2DM患者的长期预后。

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The prognostic value of serum Mg²⁺ concentration in patients with heart failure and type 2 diabetes mellitus: a retrospective cohort study.

Background: Epidemiological studies have discovered an inverse correlation between serum Mg²⁺ concentration and the risk of developing heart failure (HF) as well as atrial fibrillation (AF) in patients with type 2 diabetes mellitus (T2DM). The prognostic relevance of serum Mg²⁺ concentration in patients with HF and T2DM remains unclear.

Objectives: To assess the association of serum Mg²⁺ concentration with cardiovascular event rates in a retrospective cohort of patients with HF and T2DM.

Methods: This study included patients diagnosed with HF and T2DM in First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, from July 2018 to December 2021. The primary endpoint was cardiovascular death or rehospitalization for HF.

Results: This study included 216 patients with HF and T2DM. Patients were divided into three groups (T1 [serum Mg²⁺ level ≤ 0.8 mmol/L], T2 [0.8 < serum Mg²⁺ level ≤ 0.89 mmol/L], T3 [serum Mg²⁺ level ≥ 0.9 mmol/L]) based on serum Mg²⁺ level. The Kaplan-Meier analysis revealed that the incidence rate of primary endpoint was significantly increased among three groups (P < 0.001). In multivariate Cox regression model, elevated serum Mg²⁺ level was considered as a protective factor in the coexistence of T2DM and HF with poor prognosis.

Conclusions: Our results indicated that increased serum Mg²⁺ concentration may improve long-term prognosis of patients with HF and T2DM.

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.