Siyu Ding, Linliu Peng, Zhao Chen, Mengyuan Dong, Cuiling Tang, Yiqing Gong, Lang He, Qi Wu, Rong Qiu, Hong Jiang
{"title":"多谷氨酰胺脊髓小脑性共济失调的治疗现状和未来方向:文献计量学和视觉分析。","authors":"Siyu Ding, Linliu Peng, Zhao Chen, Mengyuan Dong, Cuiling Tang, Yiqing Gong, Lang He, Qi Wu, Rong Qiu, Hong Jiang","doi":"10.2174/011570159X360111250502055242","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Polyglutamine (polyQ) spinocerebellar ataxias (SCA) are a group of autosomal dominant neurodegenerative disorders for which no effective treatments currently exist. These conditions impose a significant burden on patients, their families, and society. Consequently, the treatment of these disorders has attracted significant global interest.</p><p><strong>Objective: </strong>We conducted this bibliometric analysis to identify the key research hotspots and predict the future research directions of this field.</p><p><strong>Methods: </strong>Studies relating to the treatment of polyQ SCA published from 1999 to 2024 were retrieved from the Web of Science Core Collection database. Relevant papers were selected using predefined inclusion and exclusion criteria. HistCite, VOSviewer, CiteSpace, and alluvial generator were used in the bibliometric analysis.</p><p><strong>Results: </strong>Overall, 935 papers were included. The number of publications in this field showed a trend toward a fluctuating increase. The United States and the University of Coimbra were the leading countries and institutions, respectively, in terms of publication number. The two most productive and highly cited authors were Luis Pereira de Almeida and Patricia Maciel. The journals Cerebellum, Human Molecular Genetics, and Movement Disorders were considered the most influential based on the number of publications and citations. Furthermore, \"new SCA types\", \"Huntington's disease\", \"clinical trial\", \"gene therapy\", \"disease models,\" and \"Aggregation clearance therapy\" emerged as current hotspots in this field, as revealed by the reference and keyword analyses.</p><p><strong>Conclusion: </strong>This study presents a systematic bibliometric analysis of research on the polyQ SCA treatment, which we hope will assist researchers in identifying the key topics and future research directions in this field.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Status and Future Directions of Treatments for Polyglutamine Spinocerebellar Ataxia: A Bibliometric and Visual Analysis.\",\"authors\":\"Siyu Ding, Linliu Peng, Zhao Chen, Mengyuan Dong, Cuiling Tang, Yiqing Gong, Lang He, Qi Wu, Rong Qiu, Hong Jiang\",\"doi\":\"10.2174/011570159X360111250502055242\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Polyglutamine (polyQ) spinocerebellar ataxias (SCA) are a group of autosomal dominant neurodegenerative disorders for which no effective treatments currently exist. These conditions impose a significant burden on patients, their families, and society. Consequently, the treatment of these disorders has attracted significant global interest.</p><p><strong>Objective: </strong>We conducted this bibliometric analysis to identify the key research hotspots and predict the future research directions of this field.</p><p><strong>Methods: </strong>Studies relating to the treatment of polyQ SCA published from 1999 to 2024 were retrieved from the Web of Science Core Collection database. Relevant papers were selected using predefined inclusion and exclusion criteria. HistCite, VOSviewer, CiteSpace, and alluvial generator were used in the bibliometric analysis.</p><p><strong>Results: </strong>Overall, 935 papers were included. The number of publications in this field showed a trend toward a fluctuating increase. The United States and the University of Coimbra were the leading countries and institutions, respectively, in terms of publication number. The two most productive and highly cited authors were Luis Pereira de Almeida and Patricia Maciel. The journals Cerebellum, Human Molecular Genetics, and Movement Disorders were considered the most influential based on the number of publications and citations. Furthermore, \\\"new SCA types\\\", \\\"Huntington's disease\\\", \\\"clinical trial\\\", \\\"gene therapy\\\", \\\"disease models,\\\" and \\\"Aggregation clearance therapy\\\" emerged as current hotspots in this field, as revealed by the reference and keyword analyses.</p><p><strong>Conclusion: </strong>This study presents a systematic bibliometric analysis of research on the polyQ SCA treatment, which we hope will assist researchers in identifying the key topics and future research directions in this field.</p>\",\"PeriodicalId\":10905,\"journal\":{\"name\":\"Current Neuropharmacology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Neuropharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/011570159X360111250502055242\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Neuropharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/011570159X360111250502055242","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景:多谷氨酰胺(polyQ)脊髓小脑共济失调(SCA)是一组常染色体显性神经退行性疾病,目前尚无有效的治疗方法。这些疾病给患者、他们的家庭和社会带来了沉重的负担。因此,这些疾病的治疗引起了全球的极大兴趣。目的:通过文献计量分析,确定该领域的重点研究热点,并预测该领域未来的研究方向。方法:从Web of Science Core Collection数据库中检索1999 - 2024年发表的与polyQ SCA治疗相关的研究。采用预先确定的纳入和排除标准选择相关论文。文献计量学分析使用HistCite、VOSviewer、CiteSpace和冲积发生器。结果:共纳入935篇论文。这一领域的出版物数量呈现出波动增长的趋势。在出版物数量方面,美国和科英布拉大学分别是领先的国家和机构。两位最多产、被引用次数最多的作家是路易斯·佩雷拉·德·阿尔梅达和帕特里夏·马西尔。《小脑》、《人类分子遗传学》和《运动障碍》杂志被认为是基于出版物和引用数量最具影响力的杂志。此外,通过文献和关键词分析,“新型SCA”、“亨廷顿病”、“临床试验”、“基因治疗”、“疾病模型”、“聚集清除疗法”成为当前该领域的热点。结论:本研究对polyQ SCA治疗的研究进行了系统的文献计量分析,希望能帮助研究人员确定该领域的重点课题和未来的研究方向。
The Status and Future Directions of Treatments for Polyglutamine Spinocerebellar Ataxia: A Bibliometric and Visual Analysis.
Background: Polyglutamine (polyQ) spinocerebellar ataxias (SCA) are a group of autosomal dominant neurodegenerative disorders for which no effective treatments currently exist. These conditions impose a significant burden on patients, their families, and society. Consequently, the treatment of these disorders has attracted significant global interest.
Objective: We conducted this bibliometric analysis to identify the key research hotspots and predict the future research directions of this field.
Methods: Studies relating to the treatment of polyQ SCA published from 1999 to 2024 were retrieved from the Web of Science Core Collection database. Relevant papers were selected using predefined inclusion and exclusion criteria. HistCite, VOSviewer, CiteSpace, and alluvial generator were used in the bibliometric analysis.
Results: Overall, 935 papers were included. The number of publications in this field showed a trend toward a fluctuating increase. The United States and the University of Coimbra were the leading countries and institutions, respectively, in terms of publication number. The two most productive and highly cited authors were Luis Pereira de Almeida and Patricia Maciel. The journals Cerebellum, Human Molecular Genetics, and Movement Disorders were considered the most influential based on the number of publications and citations. Furthermore, "new SCA types", "Huntington's disease", "clinical trial", "gene therapy", "disease models," and "Aggregation clearance therapy" emerged as current hotspots in this field, as revealed by the reference and keyword analyses.
Conclusion: This study presents a systematic bibliometric analysis of research on the polyQ SCA treatment, which we hope will assist researchers in identifying the key topics and future research directions in this field.
期刊介绍:
Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience.
The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.