{"title":"病毒感染的宿主定向免疫疗法。","authors":"Donald C Vinh","doi":"10.1097/QCO.0000000000001116","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>The limitations of pathogen-directed therapies include growing antimicrobial resistance or the complete lack of any effective antimicrobial agents. This review highlights the potential for host-directed immunotherapies.</p><p><strong>Recent findings: </strong>This review provides a current status of host-directed immunotherapies to fight infectious diseases (HIFI), defining the concept and existing modalities. Drawing on large-scale viral studies - most of which are historical with limited recent research - the review highlights key lessons for its future clinical application.</p><p><strong>Summary: </strong>HIFI represents a paradigm shift in infectious disease management, moving beyond pathogen-targeting to harnessing and modulating host immunity. This approach requires better mechanistic and pharmacologic understanding of existing modalities, development of newer agents based on tractable immunobiology, and robust clinical studies.</p>","PeriodicalId":10880,"journal":{"name":"Current Opinion in Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Host-directed immunotherapy for viral infections.\",\"authors\":\"Donald C Vinh\",\"doi\":\"10.1097/QCO.0000000000001116\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>The limitations of pathogen-directed therapies include growing antimicrobial resistance or the complete lack of any effective antimicrobial agents. This review highlights the potential for host-directed immunotherapies.</p><p><strong>Recent findings: </strong>This review provides a current status of host-directed immunotherapies to fight infectious diseases (HIFI), defining the concept and existing modalities. Drawing on large-scale viral studies - most of which are historical with limited recent research - the review highlights key lessons for its future clinical application.</p><p><strong>Summary: </strong>HIFI represents a paradigm shift in infectious disease management, moving beyond pathogen-targeting to harnessing and modulating host immunity. This approach requires better mechanistic and pharmacologic understanding of existing modalities, development of newer agents based on tractable immunobiology, and robust clinical studies.</p>\",\"PeriodicalId\":10880,\"journal\":{\"name\":\"Current Opinion in Infectious Diseases\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/QCO.0000000000001116\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/QCO.0000000000001116","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Purpose of review: The limitations of pathogen-directed therapies include growing antimicrobial resistance or the complete lack of any effective antimicrobial agents. This review highlights the potential for host-directed immunotherapies.
Recent findings: This review provides a current status of host-directed immunotherapies to fight infectious diseases (HIFI), defining the concept and existing modalities. Drawing on large-scale viral studies - most of which are historical with limited recent research - the review highlights key lessons for its future clinical application.
Summary: HIFI represents a paradigm shift in infectious disease management, moving beyond pathogen-targeting to harnessing and modulating host immunity. This approach requires better mechanistic and pharmacologic understanding of existing modalities, development of newer agents based on tractable immunobiology, and robust clinical studies.
期刊介绍：
This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.
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