小儿心脏移植后淋巴细胞增殖性疾病引起的Warburg效应引起的严重高乳酸血症，在给予硫胺素后得到解决。

IF 0.9 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology in the Young Pub Date : 2025-05-21 DOI:10.1017/S1047951125001830

Michael J Martinez, Hannah St Francis, Gloria Contreras Yametti, Rana Biary, Rakesh K Singh

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引用次数: 0

摘要

高乳酸血症是儿科心脏ICU常见且令人担忧的发现，因为它可能意味着组织灌注不足和/或缺氧。然而，重要的是要包括其他病因的乳酸升高的差异，特别是当乳酸显著升高（> 8毫摩尔/升）。我们报告一例代谢性酸中毒伴重度高乳酸血症继发于Warburg效应和推测的硫胺素缺乏症，发生在一位患有移植后淋巴细胞增生性疾病的儿童心脏移植患者身上。

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Severe hyperlactatemia from Warburg effect due to post-transplant lymphoproliferative disorder after paediatric heart transplantation with resolution following thiamine administration.

Hyperlactatemia is a common and concerning finding in the paediatric cardiac ICU as it may signify tissue hypoperfusion and/or hypoxia. However, it is important to include other aetiologies for an elevated lactate in the differential, especially when the lactate is significantly elevated (> 8 mmol/L). We present the case of metabolic acidosis with severe hyperlactatemia secondary to Warburg effect and presumed thiamine deficiency in a paediatric heart transplant patient with post-transplant lymphoproliferative disorder.

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来源期刊

Cardiology in the Young 医学-小儿科

CiteScore

1.70

自引率

10.00%

发文量

715

审稿时长

4-8 weeks

期刊介绍： Cardiology in the Young is devoted to cardiovascular issues affecting the young, and the older patient suffering the sequels of congenital heart disease, or other cardiac diseases acquired in childhood. The journal serves the interests of all professionals concerned with these topics. By design, the journal is international and multidisciplinary in its approach, and members of the editorial board take an active role in the its mission, helping to make it the essential journal in paediatric cardiology. All aspects of paediatric cardiology are covered within the journal. The content includes original articles, brief reports, editorials, reviews, and papers devoted to continuing professional development.