Estimating Hidden Cholera Burden and Intervention Effectiveness.

Cholera remains a significant public health threat in many parts of the world, with differing levels of compliance to intervention strategies and undocumented cases contributing to reservoir contamination with Vibrio cholerae at varying rates alongside reported cases. To address this, we incorporate an inapparent cholera-infected compartment into the iSIR model and equip it with parameters depicting vaccination and compliance levels for water and food sanitation, handwashing, and safe fecal disposal. Our model shows that the bacteria shedding from the inapparent infection can significantly affect the spread of cholera. Also, we identify that lowering the bacteria ingestion rate among the susceptible and controlling the bacteria shedding from reported infected are two key components for obtaining a disease-free state in the long run. The model fitting to cholera outbreaks in Haiti, Kenya, Malawi, and Zimbabwe implies that at least 88.5% of cases are inapparent, with the first reporting appearing up to 11 weeks after the start of the outbreak. Additionally, we find that the combination of water and food sanitation and handwashing is the most effective intervention strategy for reducing the cholera outbreak peak if compliance with these measures remains at moderate or high levels. However, with low compliance, safe fecal disposal of the reported infected individuals combined with vaccination coverage of the susceptible population is suggested to obtain the lowest outbreak peak.