高含硼碳量子点肿瘤内递送增强硼中子俘获治疗。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Xianwei Luo, Zhijie Wang, Mingxin Yang, Runhong Lei, Jingru Yang, Mengyao Li, Haoyang Hao, Zhicai Liu, Hongyu Tang, Bingbing Peng, Youjia Tian, Kui Chen, Ya-Nan Chang, Hui Yuan, Jianfei Tong, Linbo Zhu, Chengyu Lu, Gengmei Xing, Juan Li
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引用次数: 0

摘要

硼中子俘获治疗(BNCT)中含硼碳量子点的发展为治疗难治性肿瘤提供了一种有前景的策略。通过优化投料比、反应时间、温度和pH等参数合成碳量子点,并进行纯化,得到稳定的硼酸基富硼碳量子点(BAQDs)。该合成方法简便可靠,实现了BAQDs的规模化生产。BAQDs的硼含量为15.47 wt %,超过了临床药物硼苯丙氨酸。这也是bnct相关碳量子点材料研究的最高记录。此外,BAQDs还具有良好的水溶性、稳定性和生物相容性。实验结果表明,BAQDs在中子辐照下对4T1细胞表现出有效的抑制作用。此外,BAQDs显示出成功的肿瘤靶向递送能力。体内生物分布分析显示BAQDs在肿瘤部位有效积累,注射后0.5 h硼含量为124.32±27.64 ppm。BAQDs具有有效的硼递送能力,是一种很有前途的硼递送剂,可以通过BNCT治疗肿瘤,具有很大的临床应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intratumoral Delivery of High Boron-Containing Carbon Quantum Dots for Enhanced Boron Neutron Capture Therapy.

The development of boron-containing carbon quantum dots for boron neutron capture therapy (BNCT) offers a promising strategy for treating refractory tumors. We synthesized carbon quantum dots with optimized parameters including feed ratio, reaction time, temperature, and pH, followed by a purification process to obtain stable, boric-acid-based boron-rich carbon quantum dots (BAQDs). The large-scale production of BAQDs was implemented by this dependable and simple synthesis method. With a boron content of 15.47 wt %, the BAQDs surpassed the clinical drug boronophenylalanine. It is also the highest recorded in BNCT-related carbon quantum dot materials research. Furthermore, BAQDs exhibited excellent water solubility, stability, and biocompatibility. The experimental results demonstrated that BAQDs exhibited an effective inhibition performance against 4T1 cells under neutron irradiation. Furthermore, BAQDs displayed successful tumor-targeting delivery capabilities. In vivo biodistribution analyses revealed efficient accumulation of BAQDs at the tumor site, with a boron content of 124.32 ± 27.64 ppm 0.5 h post-injection. With their effective boron delivery capability, BAQDs represent a promising boron delivery agent for tumor therapy via BNCT, with substantial potential for clinical application.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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