{"title":"高含硼碳量子点肿瘤内递送增强硼中子俘获治疗。","authors":"Xianwei Luo, Zhijie Wang, Mingxin Yang, Runhong Lei, Jingru Yang, Mengyao Li, Haoyang Hao, Zhicai Liu, Hongyu Tang, Bingbing Peng, Youjia Tian, Kui Chen, Ya-Nan Chang, Hui Yuan, Jianfei Tong, Linbo Zhu, Chengyu Lu, Gengmei Xing, Juan Li","doi":"10.1021/acsabm.5c00479","DOIUrl":null,"url":null,"abstract":"<p><p>The development of boron-containing carbon quantum dots for boron neutron capture therapy (BNCT) offers a promising strategy for treating refractory tumors. We synthesized carbon quantum dots with optimized parameters including feed ratio, reaction time, temperature, and pH, followed by a purification process to obtain stable, boric-acid-based boron-rich carbon quantum dots (BAQDs). The large-scale production of BAQDs was implemented by this dependable and simple synthesis method. With a boron content of 15.47 wt %, the BAQDs surpassed the clinical drug boronophenylalanine. It is also the highest recorded in BNCT-related carbon quantum dot materials research. Furthermore, BAQDs exhibited excellent water solubility, stability, and biocompatibility. The experimental results demonstrated that BAQDs exhibited an effective inhibition performance against 4T1 cells under neutron irradiation. Furthermore, BAQDs displayed successful tumor-targeting delivery capabilities. In vivo biodistribution analyses revealed efficient accumulation of BAQDs at the tumor site, with a boron content of 124.32 ± 27.64 ppm 0.5 h post-injection. With their effective boron delivery capability, BAQDs represent a promising boron delivery agent for tumor therapy via BNCT, with substantial potential for clinical application.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intratumoral Delivery of High Boron-Containing Carbon Quantum Dots for Enhanced Boron Neutron Capture Therapy.\",\"authors\":\"Xianwei Luo, Zhijie Wang, Mingxin Yang, Runhong Lei, Jingru Yang, Mengyao Li, Haoyang Hao, Zhicai Liu, Hongyu Tang, Bingbing Peng, Youjia Tian, Kui Chen, Ya-Nan Chang, Hui Yuan, Jianfei Tong, Linbo Zhu, Chengyu Lu, Gengmei Xing, Juan Li\",\"doi\":\"10.1021/acsabm.5c00479\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The development of boron-containing carbon quantum dots for boron neutron capture therapy (BNCT) offers a promising strategy for treating refractory tumors. We synthesized carbon quantum dots with optimized parameters including feed ratio, reaction time, temperature, and pH, followed by a purification process to obtain stable, boric-acid-based boron-rich carbon quantum dots (BAQDs). The large-scale production of BAQDs was implemented by this dependable and simple synthesis method. With a boron content of 15.47 wt %, the BAQDs surpassed the clinical drug boronophenylalanine. It is also the highest recorded in BNCT-related carbon quantum dot materials research. Furthermore, BAQDs exhibited excellent water solubility, stability, and biocompatibility. The experimental results demonstrated that BAQDs exhibited an effective inhibition performance against 4T1 cells under neutron irradiation. Furthermore, BAQDs displayed successful tumor-targeting delivery capabilities. In vivo biodistribution analyses revealed efficient accumulation of BAQDs at the tumor site, with a boron content of 124.32 ± 27.64 ppm 0.5 h post-injection. With their effective boron delivery capability, BAQDs represent a promising boron delivery agent for tumor therapy via BNCT, with substantial potential for clinical application.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1021/acsabm.5c00479\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsabm.5c00479","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Intratumoral Delivery of High Boron-Containing Carbon Quantum Dots for Enhanced Boron Neutron Capture Therapy.
The development of boron-containing carbon quantum dots for boron neutron capture therapy (BNCT) offers a promising strategy for treating refractory tumors. We synthesized carbon quantum dots with optimized parameters including feed ratio, reaction time, temperature, and pH, followed by a purification process to obtain stable, boric-acid-based boron-rich carbon quantum dots (BAQDs). The large-scale production of BAQDs was implemented by this dependable and simple synthesis method. With a boron content of 15.47 wt %, the BAQDs surpassed the clinical drug boronophenylalanine. It is also the highest recorded in BNCT-related carbon quantum dot materials research. Furthermore, BAQDs exhibited excellent water solubility, stability, and biocompatibility. The experimental results demonstrated that BAQDs exhibited an effective inhibition performance against 4T1 cells under neutron irradiation. Furthermore, BAQDs displayed successful tumor-targeting delivery capabilities. In vivo biodistribution analyses revealed efficient accumulation of BAQDs at the tumor site, with a boron content of 124.32 ± 27.64 ppm 0.5 h post-injection. With their effective boron delivery capability, BAQDs represent a promising boron delivery agent for tumor therapy via BNCT, with substantial potential for clinical application.
期刊介绍:
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.