Front Cover: Multigram Synthesis of 3-Azabicyclo[3.1.1]heptane Derivatives Including Bicyclic Thalidomide Analogs (Eur. J. Org. Chem. 17/2025)

The Front Cover shows a wizard casting a conformational restriction spell onto a molecule of thalidomide. The magical transformation leads to a 3-azabicyclo[3.1.1]heptane derivative—a promising scaffold for potential drug-discovery applications. In their Research Article (DOI: 10.1002/ejoc.202400938), O. O. Grygorenko and co-authors describe a multigram synthetic approach toward such molecules (with almost no magic involved). In particular, a series of 1-substituted 3-azabicyclo[3.1.1]heptanes, that is, monoprotected diamine building blocks, thalidomide analogs, and troxipide mimetics, were prepared with high efficiency. Artwork by Vitalii Boklashchuk.