菲律宾幽门螺杆菌:血清阳性和缺乏与全身性炎症相关的社会和生态决定因素

IF 1.6 4区 医学 Q1 ANTHROPOLOGY
Cassie C. Lee, Aaron A. Miller, Paula S. Tallman, Shalean M. Collins, Theresa E. Gildner, Tara J. Cepon-Robins, Nanette R. Lee, Thomas W. McDade
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引用次数: 0

摘要

幽门螺杆菌(h.p ylori)是一种感染胃的细菌,与各种胃肠道结局和心血管疾病风险增加有关。我们研究了性别的作用以及与幽门螺杆菌血清阳性(n = 124)相关的社会和生态因素,以及血清阳性与全系统炎症(n = 116)之间的关系。数据来自宿务纵向健康和营养调查,当时参与者为21岁。Anti-H。分别测定干血斑和血浆中幽门螺杆菌抗体浓度和c反应蛋白(CRP)浓度。该样本幽门螺杆菌血清阳性率为32.3%。在调整性别的逻辑回归分析中,较高的社会经济地位(即资产指数)与幽门螺杆菌血清阳性的可能性降低相关(OR = 0.723, p = 0.015)。较高的资产(OR = 0.688, p = 0.002)和较高的卫生水平(OR = 0.754, p = 0.026)与幽门螺杆菌血清阳性几率降低相关。家庭附近任何程度的粪便,相对于没有粪便(低粪便OR = 3.45, p = 0.036;高粪便OR = 3.96, p = 0.021),与血清阳性几率增加相关。性别与血清阳性无关。血清阳性与CRP浓度无关(p = 0.52)。我们的研究结果支持社会经济和卫生因素对幽门螺杆菌感染风险的影响。这些发现为先前未确定感染危险因素的人群中幽门螺杆菌血清阳性相关因素提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation

Helicobacter pylori (H. pylori) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological factors associated with H. pylori seropositivity (n = 124) and the relationship between seropositivity and systemic inflammation (n = 116) among adults in Metro Cebu, Philippines. Data were drawn from the Cebu Longitudinal Health and Nutrition Survey when participants were 21 years old. Anti-H. pylori antibody concentrations and C-reactive protein (CRP) concentrations were analyzed in dried blood spots and plasma, respectively. The seroprevalence of H. pylori in this sample was 32.3%. In logistic regression analyses adjusting for sex, higher socioeconomic status (i.e., asset index) was associated with decreased likelihood of H. pylori seropositivity (OR = 0.723, p = 0.015). Higher assets (OR = 0.688, p = 0.002) and higher hygiene (OR = 0.754, p = 0.026) were associated with decreased odds of H. pylori seropositivity. Any level of excrement near the household, relative to no excrement (low excrement OR = 3.45, p = 0.036; high excrement OR = 3.96, p = 0.021), was associated with increased odds of seropositivity. Sex was not associated with seropositivity. Seropositivity was not associated with CRP concentrations (p = 0.52). Our results support the role of both socioeconomic and hygienic determinants of H. pylori infection risk. These findings provide new insight into factors associated with H. pylori seropositivity in a population with no previously identified infection risk factors.

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来源期刊
CiteScore
4.80
自引率
13.80%
发文量
124
审稿时长
4-8 weeks
期刊介绍: The American Journal of Human Biology is the Official Journal of the Human Biology Association. The American Journal of Human Biology is a bimonthly, peer-reviewed, internationally circulated journal that publishes reports of original research, theoretical articles and timely reviews, and brief communications in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, the Journal also publishes abstracts of research presented at its annual scientific meeting and book reviews relevant to the field. The Journal seeks scholarly manuscripts that address all aspects of human biology, health, and disease, particularly those that stress comparative, developmental, ecological, or evolutionary perspectives. The transdisciplinary areas covered in the Journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology, and evolution, along with their interactions. The Journal publishes basic, applied, and methodologically oriented research from all areas, including measurement, analytical techniques and strategies, and computer applications in human biology. Like many other biologically oriented disciplines, the field of human biology has undergone considerable growth and diversification in recent years, and the expansion of the aims and scope of the Journal is a reflection of this growth and membership diversification. The Journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscripts of unusual interest.
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