吩噻嗪基咪唑衍生物的微波合成及生物学研究

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI:10.1134/S1070363225600249

P. Idavathi Gunaseeli, Y. Jaya Vinse Ruban, K. Venkatesan

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引用次数: 0

摘要

以乙酸铵、1,2-二酮和烷基取代- 10h -吩噻嗪-3-乙醛为原料，以KH2PO4为催化剂，采用常规和微波辐照法制备了一系列三取代咪唑衍生物。所有化合物对选定的革兰氏阳性和阴性菌株的抗菌性能进行了测试，所得化合物均表现出良好至中等的抗菌活性。对合成的衍生物进行了抗氧化研究，结果表明该化合物具有中等至较好的抗氧化活性。

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Microwave Assisted Synthesis and Biological Studies of Phenothiazine-Based Imidazole Derivatives

A series of tri-substituted imidazole derivatives were produced by combining ammonium acetate, 1,2-diketones, and alkyl substituted-10H-phenothiazine-3-carbaldehyde using KH₂PO₄ catalyst in both conventional and microwave irradiation method. All substances were tested for their antibacterial properties against the chosen gram positive and negative bacterial strains, all the produced compounds demonstrated good to moderate activity. Synthesized derivatives were evaluated for antioxidant studies and the results showed that the compound showed moderate to better activity.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.