Yexi Zhang, Huiye Liu, Dongzhao Hao, Chuanmei Tang, Lei Yue, Rongxin Su, Wei Qi, Xuemei Zhang, Yuefei Wang
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Synthesis of gold nanoclusters mediated by bifunctional peptides and their self-assembly behaviour under proportional regulation
Gold nanoclusters (AuNCs) are among the most stable nanoclusters and are nanomaterials with a particle size of approximately 2 nm. AuNCs have demonstrated considerable potential in the biomedical field due to their distinctive optical properties and exceptional biocompatibility. In this paper, two bifunctional peptides were designed and synthesised, comprising a domain with cell-penetrating peptide sequences and a domain with the capacity to biomineralise and capture Au clusters. Two novel peptide-AuNCs were synthesised using a one-step reduction method via bifunctional peptides. The impact of varying peptide/HAuCl4 ratios on the nanocluster structure and fluorescence characteristics was investigated. The findings indicate that the peptide ratio influences the fluorescence colour of the nanoclusters. And as the proportion increases, nanoclusters tend to form a ligand pattern.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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