风湿性多肌痛患者新型炎症生物标志物的临床特征及意义：一项来自中国的单中心研究

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-05-22 DOI:10.1016/j.cyto.2025.156953

Ruohan Yu , Miao Miao , Siying Li , Xue Li , Haihong Yao , Yuan Jia

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引用次数: 0

摘要

目的风湿多肌痛（PMR）是一种主要影响老年人的炎症性风湿病，其特征是近端肌肉疼痛和僵硬。与欧洲人群相比，中国人群的PMR患病率相对较低，导致中国患者的临床表现和血清学特征研究有限。我们的目的是分析中国PMR患者的特征，并探讨新的炎症生物标志物的意义。方法回顾性收集1992 ~ 2022年北京大学人民医院诊断为PMR的住院患者的医疗资料。审查了电子医疗记录。我们分析了PMR患者的临床和实验室特征，并探索了新的炎症标志物。结果共纳入87例患者，男女比例为1:6 .6。最常见的临床表现是肩带疼痛（96.6%），其次是骨盆疼痛（89.7%）、颈椎疼痛（63.2%）、晨僵直（48.3%）和腰椎疼痛（40.2%）。颈椎疼痛在女性患者中比在男性患者中更常见。87例PMR患者中有12例（13.8%）合并巨细胞动脉炎（GCA）。厌食症在GCA患者中更为常见（P = 0.024）。IL-6是最常升高的细胞因子，并与发热显著相关。全身免疫炎症指数（SII）、血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR）与c反应蛋白（CRP）和红细胞沉降率（ESR）相关。结论肩带和骨盆带疼痛是PMR最常见的表现。13.8%的患者并发GCA。IL-6水平升高与发热显著相关，提示IL-6可能与PMR全身性炎症有关。SII、NLR和PLR与ESR和CRP水平呈正相关，提示这些新标志物是PMR患者有希望的炎症标志物。

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The clinical characteristics and significance of novel inflammatory biomarkers in patients with polymyalgia rheumatica: A single-center study from China

Objective

Polymyalgia rheumatica (PMR) is an inflammatory rheumatic disorder predominantly affecting older adults, characterized by proximal muscle pain and stiffness. The prevalence of PMR in Chinese population is relatively low comparing to European population, resulting in limited research regarding its clinical manifestations and serological characteristics among Chinese patients. We aimed to analyse the features of Chinese patients with PMR and explore the significance of novel inflammatory biomarkers.

Methods

We retrospectively collected the medical data of hospitalized patients diagnosed with PMR at Peking University People's Hospital between 1992 and 2022. Electronic medical records were reviewed. We analyzed the clinical and laboratory characteristics of patients with PMR, and explored new inflammatory markers.

Results

A total of 87 patients were included in the study, with a male-to-female ratio of 1:2.6. The most common clinical manifestation was shoulder girdle pain (96.6 %), followed by pelvic girdle pain (89.7 %), cervical spine pain (63.2 %), morning stiffness (48.3 %), and lumbar spine pain (40.2 %). Cervical spine pain was more common in female patients than in male patients. 12 out of 87 (13.8 %) patients with PMR were complicated with giant cell arteritis (GCA). Anorexia was more commonly seen in patients with GCA (P = 0.024). IL-6 was the most frequently elevated cytokine and was significantly associated with fever. The systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) were correlated with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).

Conclusion

Shoulder girdle and pelvic girdle pain were the most common manifestations of PMR. 13.8 % of the patients had concurrent GCA. Elevated levels of IL-6 were significantly correlated with fever, indicating that IL-6 may contribute to the systemic inflammation of PMR. SII, NLR and PLR were positively associated with the levels of ESR and CRP, suggesting that these novel markers are promising inflammatory markers in patients with PMR.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.