三唑/苯并咪唑杂化分子的合成、抗真菌活性及硅研究

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-04-18 DOI:10.1080/00397911.2025.2486104

Ganesh Babu N. V. N. Kolukula (Methodology) , Penke Vijaya Babu (Writing – original draft) , Korripally Premsagar (Validation) , Sibbala Subramanyam (Supervision)

{"title":"三唑/苯并咪唑杂化分子的合成、抗真菌活性及硅研究","authors":"Ganesh Babu N. V. N. Kolukula (Methodology) , Penke Vijaya Babu (Writing – original draft) , Korripally Premsagar (Validation) , Sibbala Subramanyam (Supervision)","doi":"10.1080/00397911.2025.2486104","DOIUrl":null,"url":null,"abstract":"<div><div>A new series of triazole/benzimidazole hybrid molecules are synthesized using copper-catalyzed click reaction (CuAAC). All the newly synthesized compounds were well-characterized by analytical data. Most of the target compounds displayed potential anti-fungal activity against various Candida strains. In particular, compound <strong>6a</strong> exhibited the highest antifungal activity against the tested Candida strains across all concentrations, highlighting its potential as a therapeutic agent, and the activity was supported by extensive in silico studies.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"55 8","pages":"Pages 608-617"},"PeriodicalIF":1.8000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, anti-fungal activities and in silico studies of triazole/benzimidazole hybrid molecules\",\"authors\":\"Ganesh Babu N. V. N. Kolukula (Methodology) , Penke Vijaya Babu (Writing – original draft) , Korripally Premsagar (Validation) , Sibbala Subramanyam (Supervision)\",\"doi\":\"10.1080/00397911.2025.2486104\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A new series of triazole/benzimidazole hybrid molecules are synthesized using copper-catalyzed click reaction (CuAAC). All the newly synthesized compounds were well-characterized by analytical data. Most of the target compounds displayed potential anti-fungal activity against various Candida strains. In particular, compound <strong>6a</strong> exhibited the highest antifungal activity against the tested Candida strains across all concentrations, highlighting its potential as a therapeutic agent, and the activity was supported by extensive in silico studies.</div></div>\",\"PeriodicalId\":22119,\"journal\":{\"name\":\"Synthetic Communications\",\"volume\":\"55 8\",\"pages\":\"Pages 608-617\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-04-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synthetic Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S0039791125000335\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthetic Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0039791125000335","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

利用铜催化咔嗒反应（CuAAC）合成了一系列新的三唑/苯并咪唑杂化分子。所有新合成的化合物都通过分析数据得到了很好的表征。大多数目标化合物对各种念珠菌菌株显示出潜在的抗真菌活性。特别是，化合物6a在所有浓度下对所测试的念珠菌菌株表现出最高的抗真菌活性，突出了其作为治疗剂的潜力，并且该活性得到了广泛的计算机研究的支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Synthesis, anti-fungal activities and in silico studies of triazole/benzimidazole hybrid molecules

A new series of triazole/benzimidazole hybrid molecules are synthesized using copper-catalyzed click reaction (CuAAC). All the newly synthesized compounds were well-characterized by analytical data. Most of the target compounds displayed potential anti-fungal activity against various Candida strains. In particular, compound 6a exhibited the highest antifungal activity against the tested Candida strains across all concentrations, highlighting its potential as a therapeutic agent, and the activity was supported by extensive in silico studies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.