苯基卤化物、Na2S2O3和胺的自催化反应：一锅制硫苯酰胺的简单有效途径

IF 2.1 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Sulfur Chemistry Pub Date : 2025-05-04 DOI:10.1080/17415993.2025.2473737

Nasser Zarinderakht , Mohammad Abbasi , Najmeh Nowrouzi

{"title":"苯基卤化物、Na2S2O3和胺的自催化反应：一锅制硫苯酰胺的简单有效途径","authors":"Nasser Zarinderakht , Mohammad Abbasi , Najmeh Nowrouzi","doi":"10.1080/17415993.2025.2473737","DOIUrl":null,"url":null,"abstract":"<div><div>A new efficient, one-pot method to get thiobenzamide compounds from benzyl halides, amines, and Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub> is reported. A benzylic halide is treated with Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub> in DMSO until the halide is completely consumed. Next, the reaction is continued by adding a primary or secondary amine to the reaction mixture to synthesize thiobenzamides simply. This procedure does not require a special catalyst or any additive to afford thiobenzamides in good to excellent yields.</div></div>","PeriodicalId":17081,"journal":{"name":"Journal of Sulfur Chemistry","volume":"46 3","pages":"Pages 393-400"},"PeriodicalIF":2.1000,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Self-catalyzed, reaction of benzyl halides, Na2S2O3, and amines: a one-pot, simple, and efficient route to thiobenzamides\",\"authors\":\"Nasser Zarinderakht , Mohammad Abbasi , Najmeh Nowrouzi\",\"doi\":\"10.1080/17415993.2025.2473737\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A new efficient, one-pot method to get thiobenzamide compounds from benzyl halides, amines, and Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub> is reported. A benzylic halide is treated with Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub> in DMSO until the halide is completely consumed. Next, the reaction is continued by adding a primary or secondary amine to the reaction mixture to synthesize thiobenzamides simply. This procedure does not require a special catalyst or any additive to afford thiobenzamides in good to excellent yields.</div></div>\",\"PeriodicalId\":17081,\"journal\":{\"name\":\"Journal of Sulfur Chemistry\",\"volume\":\"46 3\",\"pages\":\"Pages 393-400\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-05-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Sulfur Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1741599325000133\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sulfur Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1741599325000133","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

报道了一种从卤苄、胺和Na2S2O3中提取硫代苯甲酰胺化合物的高效一锅法。苯基卤化物在DMSO中用Na2S2O3处理，直到卤化物完全消耗。接下来，通过在反应混合物中加入伯胺或仲胺来继续反应，以简单地合成硫苯酰胺。这个过程不需要特殊的催化剂或任何添加剂，以提供良好的到优异的产量的硫苯酰胺。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Self-catalyzed, reaction of benzyl halides, Na2S2O3, and amines: a one-pot, simple, and efficient route to thiobenzamides

A new efficient, one-pot method to get thiobenzamide compounds from benzyl halides, amines, and Na₂S₂O₃ is reported. A benzylic halide is treated with Na₂S₂O₃ in DMSO until the halide is completely consumed. Next, the reaction is continued by adding a primary or secondary amine to the reaction mixture to synthesize thiobenzamides simply. This procedure does not require a special catalyst or any additive to afford thiobenzamides in good to excellent yields.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Sulfur Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.10

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science. Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.