激活素a激活的ALK4诱导致病性Th17参与系统性红斑狼疮相关肺动脉高压的内皮-间质转化

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2025-05-21 DOI:10.1002/art.43235

Shuliang Jing, Junyan Qian, Hongjie Ying, Pei Mao, Mingxin Yao, Zhihong Wu, Harm J Bogaard, Lie Wang, Mengtao Li, Jun Yang

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引用次数: 0

摘要

自身免疫性疾病，如系统性红斑狼疮（SLE），与肺动脉高压（PAH）有关，这是一种可导致心力衰竭的疾病。然而，T细胞是否也有助于SLE中PAH的发生，尚不清楚。本研究的目的是阐明激活素A和激活受体信号在SLE-PAH中的作用。

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Activin A-activated ALK4 induces pathogenic Th17 involved endothelial–mesenchymal transition in systemic lupus erythematosus-associated pulmonary arterial hypertension

Autoimmune diseases, such as systemic lupus erythematosus (SLE), are associated with pulmonary arterial hypertension (PAH), a condition that can lead to heart failure. However, whether T cells also contribute to the occurrence of PAH in SLE, has not been clarified. The objective of this study was to elucidate the role of Activin A and activated receptor signaling in SLE-PAH.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.