低PlGF百分数妊娠中胎盘功能障碍亚型的评估。

IF 6.9 1区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Kirsty M M Vincent,Terence Garner,Adam Stevens,Elizabeth C Cottrell,Jenny E Myers,Lucy E Higgins
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引用次数: 0

摘要

低循环胎盘生长因子(PlGF)浓度被认为是胎盘功能障碍的标志,胎盘功能障碍是子痫前期和胎儿生长受限的主要原因。除了医源性分娩外,由于其异质性,没有有效的治疗方法。我们假设低循环PlGF妊娠存在bbb1亚型胎盘功能障碍。方法匹配胎盘绒毛和母体血浆样本(低PlGF <5, n=19;正常PlGF≥5百位数,n=20)采集自无并发症妊娠和合并先兆子痫、胎儿生长受限或慢性高血压的妊娠。从绒毛样本中获得转录组学和代谢组学数据集,并用于进行聚类分析。比较聚类之间的临床结果,以及随后的通路分析。结果多组学聚类分析得到3个分子簇。第1组主要由低PlGF患者组成(9/10);聚类2的PlGF结果不同(低,n=8/20;正常,n=12/20),而聚类3主要由PlGF结果正常的人组成(n=7/9)。第1组的出生体重明显较低,同时早发性先兆子痫的发生率也有所增加。然而,通常与胎盘功能障碍相关的途径仅在第2类中被确定。结论多组学分析揭示了与低循环PlGF相关的2种潜在胎盘功能障碍亚型。这些结果支持了先前关于子痫前期亚型存在的研究。临床结果比较显示1组为重症亚型;然而,通路分析与此相矛盾。提高对亚型病因学的了解可以使妊娠合并胎盘功能障碍的治疗方法更加个性化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing Placental Dysfunction Subtypes in Pregnancies With a Low PlGF Centile.
BACKGROUND A low circulating placental growth factor (PlGF) concentration is considered a marker of placental dysfunction, the predominant cause of preeclampsia and fetal growth restriction. Besides iatrogenic delivery, there are no effective treatments, potentially due to its heterogeneity. We hypothesize that >1 subtype of placental dysfunction exists in pregnancies with a low circulating PlGF. METHODS Matched placental villous and maternal plasma samples (low PlGF <5th, n=19; normal PlGF ≥5th centile, n=20) were collected from uncomplicated pregnancies and those complicated by 1 or a combination of preeclampsia, fetal growth restriction, or chronic hypertension. Transcriptomic and metabolomic data sets were obtained from villous samples and used to perform cluster-of-cluster analysis. Clinical outcomes were compared between clusters, as well as subsequent pathway analysis. RESULTS Multiomic cluster-of-cluster analysis resulted in 3 molecular clusters. Cluster 1 predominantly consisted of those with a low PlGF (9/10); PlGF results in cluster 2 varied (low, n=8/20; normal, n=12/20), while cluster 3 mainly comprised of those with a normal PlGF result (n=7/9). Birthweight was significantly lower in cluster 1, as well as an increased incidence of early-onset preeclampsia. However, pathways commonly associated with placental dysfunction were only identified in cluster 2. CONCLUSIONS Multiomic analysis revealed 2 potential subtypes of placental dysfunction associated with a low circulating PlGF. These results support previous studies suggesting the existence of preeclampsia subtypes. Clinical outcome comparisons indicate cluster 1 as the severe subtype; however, pathway analysis contradicted this. Improved understanding of subtype etiology could enable a more personalized therapeutic approach for pregnancies complicated by placental dysfunction.
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来源期刊
Hypertension
Hypertension 医学-外周血管病
CiteScore
15.90
自引率
4.80%
发文量
1006
审稿时长
1 months
期刊介绍: Hypertension presents top-tier articles on high blood pressure in each monthly release. These articles delve into basic science, clinical treatment, and prevention of hypertension and associated cardiovascular, metabolic, and renal conditions. Renowned for their lasting significance, these papers contribute to advancing our understanding and management of hypertension-related issues.
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