GEPIA3：用于癌症研究的增强药物敏感性和相互作用网络分析。

IF 16.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleic Acids Research Pub Date : 2025-05-21 DOI:10.1093/nar/gkaf423

Yu-Jian Kang,Lingjie Pan,Yiyu Liu,Zhengqin Rong,Jiaxi Liu,Fenglin Liu

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引用次数: 0

摘要

GEPIA系列为基因表达数据的泛癌症分析提供了强大且广泛使用的工具。在后基因组时代，一个主要的挑战是解开受多因素影响的复杂调控关系，发现基于基因的精确治疗方法。在这里，我们提出了GEPIA3， GEPIA3是GEPIA的高级版本，它提供了各种癌症类型的基因/蛋白质相互作用的综合分析。该版本有助于利用真实世界患者数据和细胞系筛选超过1000种治疗药物的治疗敏感性的调查，以及来自全基因组项目的泛癌症分析的RNA改变的整合。GEPIA3是对原有平台的显著增强，能够深入探索基因调控和癌症表型，从而支持鉴定新的生物标志物和治疗靶点。GEPIA3可在https://gepia3.bioinfoliu.com公开访问。

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GEPIA3: Enhanced drug sensitivity and interaction network analysis for cancer research.

The GEPIA series has provided robust and widely used tools for pan-cancer analysis of gene expression data. In the post-genomic era, a major challenge lies in deconvoluting complex regulatory relationship influenced by multiple factors and discovering gene-based precision therapeutics. Here we present GEPIA3, an advanced version of GEPIA that provides a comprehensive analysis of gene/protein interactions across various cancer types. This version facilitates the investigation of treatment sensitivity utilizing both real-world patient data and cell line screens for over 1000 therapeutic agents, as well as the integration of RNA alterations derived from the pan-cancer analysis of whole genomes project. GEPIA3 represents a significant enhancement of the original platform, enabling in-depth exploration of gene regulation and cancer phenotypes, thereby supporting the identification of novel biomarkers and therapeutic targets. GEPIA3 is publicly accessible at https://gepia3.bioinfoliu.com.

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来源期刊

Nucleic Acids Research 生物-生化与分子生物学

CiteScore

27.10

自引率

4.70%

发文量

1057

审稿时长

2 months

期刊介绍： Nucleic Acids Research (NAR) is a scientific journal that publishes research on various aspects of nucleic acids and proteins involved in nucleic acid metabolism and interactions. It covers areas such as chemistry and synthetic biology, computational biology, gene regulation, chromatin and epigenetics, genome integrity, repair and replication, genomics, molecular biology, nucleic acid enzymes, RNA, and structural biology. The journal also includes a Survey and Summary section for brief reviews. Additionally, each year, the first issue is dedicated to biological databases, and an issue in July focuses on web-based software resources for the biological community. Nucleic Acids Research is indexed by several services including Abstracts on Hygiene and Communicable Diseases, Animal Breeding Abstracts, Agricultural Engineering Abstracts, Agbiotech News and Information, BIOSIS Previews, CAB Abstracts, and EMBASE.