环境电荷介导的纳米压电催化声动力疗法。

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-05-20 DOI:10.1021/acs.nanolett.5c02110

Jiachen Xu,Xiaomin Ma,Jingming Wang,Chengmei Zhang,Xiangdong Liu,Yuanyuan Qu,Mingwen Zhao,Weifeng Li,Weimin Huang,Yong-Qiang Li

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引用次数: 0

摘要

压电催化在声动力治疗（SDT）中受到越来越多的关注。然而，由于能带理论和压电效应理论的突出而又相互矛盾，其机理仍然存在争议。前者只关注载体的作用，而后者只强调筛选收费的贡献。这种分歧极大地阻碍了压电催化介导的SDT的发展。在这里，我们展示了载流子（电子/空穴）和筛选电荷在压电催化中的联合作用，并提出了一种基于缺陷BaTiO3@TiO2压电纳米粒子（D-B@T）的新的压电催化模型（称为环境电荷介导的纳米压电催化）。载体与筛选电荷的协同作用，使D-B@T在超声刺激下具有优越的活性氧生成能力，能够有效地在体内SDT治疗细菌性肺炎。本研究对压电催化有了深刻的理解，并指导了SDT高性能压电纳米声敏剂的合理设计。

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Environmental Charge-Mediated Nanopiezocatalysis for Sonodynamic Therapy.

Piezocatalysis garners growing attention in sonodynamic therapy (SDT). However, its mechanism remains controversial due to the prominent but conflicting theories of energy band and piezoelectric effect. The former just focuses on the role of carriers, while the latter emphasizes only the contribution of screening charges. This divergence greatly hinders the development of piezocatalysis-mediated SDT. Here, we demonstrate the combined action of carriers (electrons/holes) and screening charges on piezocatalysis and propose a new piezocatalytic model (termed environmental charge-mediated nanopiezocatalysis) based on defective BaTiO3@TiO2 piezoelectric nanoparticles (D-B@T). The synergistic effect of carriers and screening charges endows D-B@T with superior reactive oxygen species generation capability under ultrasound stimulation and enables effective SDT treatment of bacterial pneumonia in vivo. This work offers an insightful understanding of piezocatalysis and guides the rational design of high-performance piezoelectric nanosonosensitizers for SDT.

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.