[Update Raynaud Phenomenon].

Several new aspects concerning Raynaud's phenomenon (RP) are highlighted. Low weight is a known factor for the manifestation of RP, but RP may also be triggered by intended or unintended weight loss. RP is more frequent in presence of depression or anxiety disorders which may be revealed by questionnaires. The socioeconomic effect of RP is small in most of the patients; as far as they aren't engaged in professions with cold exposition, ability to work is not restricted. However, if systemic sclerosis (SSc) is the underlying disease of RP, disability rates are considerable due to finger necrosis and soft tissue damages. Capillaroscopy may be a decisive tool to disclose SSc being the underlying disorder for RP. However, a pathological capillaroscopy pattern is no proof of SSc and not diagnostic if antinuclear antibodies are absent; the predictive value of puffy fingers and specific antibodies is superior. Medical treatment is restricted to severe forms of RP, which are often caused by SSc. Calcium channel blockers have the highest propagation but should not be used in case of digital ulcers. Prostanoids seem to be of greater value, phophodiesterase inhibitors have a small effect and Bosentan may reduce the appearance of new ulcers. Botulinum-A may be considered if ulcers and pain are prevailing. With all options of treatment a considerable placebo effect has to be regarded. Promising case series for several drugs were followed by disillusioning controlled studies. Autologous fat or adipose-derived stem cell grafting is a recent therapeutic approach for SSc patients with severe and disabling course of disease who cannot use their hands anymore, but the best form of application is not yet determined.