外泌体/基于外泌体的药物制剂与超声的联合应用。

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Journal of Materials Chemistry B Pub Date : 2025-05-20 DOI:10.1039/D4TB01530D

Xiuli Wen and Yi Hao

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引用次数: 0

摘要

外泌体是由多种细胞分泌的直径为30- 150nm的细胞外小泡，含有核酸、蛋白质、脂类等多种活性物质。利用外泌体作为药物载体靶向递送治疗药物的研究已经进行了很长时间。超声被认为是一种非侵入性的诊断和治疗方法，有助于药物装载和靶向递送，细胞摄取和治疗。本文综述了超声技术在辅助药物外泌体装载、外泌体药物制剂靶向递送、细胞摄取和治疗等方面的应用，并探讨了外泌体/外泌体药物制剂与超声联合应用的前景。

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The combined application of exosomes/exosome-based drug preparations and ultrasound

Exosomes are small extracellular vesicles with a diameter of 30–150 nm, secreted by a variety of cells and containing various active substances such as nucleic acids, proteins and lipids. The use of exosomes as drug carriers for targeted delivery of therapeutics has been studied for a long time. Ultrasound is recognized as a non-invasive diagnostic and therapeutic method for assisting drug loading and targeted delivery, cellular uptake and therapy. In this review, we summarize the applications of ultrasound in assisting drug loading into exosomes, targeted delivery of exosome-based drug formulations, cellular uptake, and therapy, and explore the prospects for the combined application of exosomes/exosome-based drug formulations and ultrasound.

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices