{"title":"揭开妊娠糖尿病患者血糖变异性的神秘面纱：一项横断面观察研究。","authors":"Anamika Baghel, Aruna Nigam, Nidhi Gupta","doi":"10.1007/s13224-024-01992-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To study glycemic variability (GV) and 24-h ambulatory glucose profile (AGP) in gestational diabetes mellitus (GDM) patients who were apparently controlled on drugs and their correlation with fetomaternal outcomes.</p><p><strong>Methodology: </strong>In this cross-sectional observational study, 40 gestational diabetic pregnancies on pharmacotherapy were recruited. Flash glucose monitor was used to record AGP between 32 and 36 weeks of gestation. A total of 600 patient days with 58,600 glucose values were analyzed.</p><p><strong>Results: </strong>Variables of GV: Mean amplitude of glycemic excursion (<i>p</i> = 0.001), standard deviation (<i>p</i> = 0.001), Continuous Overall Net Glycemic Action (<i>p</i> = 0.002) and High Blood Glucose Index (<i>p</i> = 0.001) were significantly high in GDM group when compared to normoglycemic patients and these were well correlated with poor fetomaternal outcome in this group. Time in range was also significantly altered in GDM group. (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>High GV and time in range are the important parameters which get altered in GDM pregnancies despite apparent control of blood glucose, and this can be a reason of adverse fetomaternal outcomes in these pregnancies.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 Suppl 1","pages":"333-339"},"PeriodicalIF":0.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085490/pdf/","citationCount":"0","resultStr":"{\"title\":\"Demystifying Glycemic Variability in GDM Pregnancies: A Cross-Sectional Observational Study.\",\"authors\":\"Anamika Baghel, Aruna Nigam, Nidhi Gupta\",\"doi\":\"10.1007/s13224-024-01992-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To study glycemic variability (GV) and 24-h ambulatory glucose profile (AGP) in gestational diabetes mellitus (GDM) patients who were apparently controlled on drugs and their correlation with fetomaternal outcomes.</p><p><strong>Methodology: </strong>In this cross-sectional observational study, 40 gestational diabetic pregnancies on pharmacotherapy were recruited. Flash glucose monitor was used to record AGP between 32 and 36 weeks of gestation. A total of 600 patient days with 58,600 glucose values were analyzed.</p><p><strong>Results: </strong>Variables of GV: Mean amplitude of glycemic excursion (<i>p</i> = 0.001), standard deviation (<i>p</i> = 0.001), Continuous Overall Net Glycemic Action (<i>p</i> = 0.002) and High Blood Glucose Index (<i>p</i> = 0.001) were significantly high in GDM group when compared to normoglycemic patients and these were well correlated with poor fetomaternal outcome in this group. Time in range was also significantly altered in GDM group. (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>High GV and time in range are the important parameters which get altered in GDM pregnancies despite apparent control of blood glucose, and this can be a reason of adverse fetomaternal outcomes in these pregnancies.</p>\",\"PeriodicalId\":51563,\"journal\":{\"name\":\"Journal of Obstetrics and Gynecology of India\",\"volume\":\"75 Suppl 1\",\"pages\":\"333-339\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085490/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Obstetrics and Gynecology of India\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13224-024-01992-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obstetrics and Gynecology of India","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13224-024-01992-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/27 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Demystifying Glycemic Variability in GDM Pregnancies: A Cross-Sectional Observational Study.
Aim: To study glycemic variability (GV) and 24-h ambulatory glucose profile (AGP) in gestational diabetes mellitus (GDM) patients who were apparently controlled on drugs and their correlation with fetomaternal outcomes.
Methodology: In this cross-sectional observational study, 40 gestational diabetic pregnancies on pharmacotherapy were recruited. Flash glucose monitor was used to record AGP between 32 and 36 weeks of gestation. A total of 600 patient days with 58,600 glucose values were analyzed.
Results: Variables of GV: Mean amplitude of glycemic excursion (p = 0.001), standard deviation (p = 0.001), Continuous Overall Net Glycemic Action (p = 0.002) and High Blood Glucose Index (p = 0.001) were significantly high in GDM group when compared to normoglycemic patients and these were well correlated with poor fetomaternal outcome in this group. Time in range was also significantly altered in GDM group. (p < 0.001).
Conclusion: High GV and time in range are the important parameters which get altered in GDM pregnancies despite apparent control of blood glucose, and this can be a reason of adverse fetomaternal outcomes in these pregnancies.
期刊介绍：
Journal of Obstetrics and Gynecology of India (JOGI) is the official journal of the Federation of Obstetrics and Gynecology Societies of India (FOGSI). This is a peer- reviewed journal and features articles pertaining to the field of obstetrics and gynecology. The Journal is published six times a year on a bimonthly basis. Articles contributed by clinicians involved in patient care and research, and basic science researchers are considered. It publishes clinical and basic research of all aspects of obstetrics and gynecology, community obstetrics and family welfare and subspecialty subjects including gynecological endoscopy, infertility, oncology and ultrasonography, provided they have scientific merit and represent an important advance in knowledge. The journal believes in diversity and welcomes and encourages relevant contributions from world over. The types of articles published are: · Original Article· Case Report · Instrumentation and Techniques · Short Commentary · Correspondence (Letter to the Editor) · Pictorial Essay
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