阴道液肌酐水平检测膜破裂。

IF 0.7 Q4 OBSTETRICS & GYNECOLOGY
Palugula Sushma Sree, E Gomathy, R K Saxena
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引用次数: 0

摘要

当胎龄小于37周时,由于子宫收缩开始前胎膜破裂(ROM)导致羊水从阴道泄漏,这种情况称为早产胎膜早破。在分娩开始前,37周后发生ROM,称为产前胎膜破裂。本研究旨在探讨阴道液肌酐水平是否可用于诊断女性rom。目的:研究阴道液肌酐诊断膜破裂的敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)。方法:本研究纳入60例胎龄28 ~ 40周的MVJMC & RH住院的单胎妊娠孕妇。这是一项基于医院的前瞻性比较研究。研究组包括30名抱怨阴道漏液的孕妇(病例组)和30名从产房随机招募的无ROM的孕妇(对照组)。如果存在明显的“泄漏”,则用注射器收集3毫升阴道液样本。如果膜完好,则在阴道后穹窿内滴入5ml无菌生理盐水溶液,用同一注射器抽出3ml液体,送去阴道液肌酐水平测定。结果:病例组和对照组阴道液肌酐平均值为1.50±0.25 mg/dL,标准差为0.52±0.28 mg/dL。采用受试者操作特征(ROC)曲线坐标,平衡敏感性和特异性,建立理想的截止评分。选择临界值为1.050 mg/dL,灵敏度为93.1%,特异性为90.3%,PPV为90.0%,NPV为93.3%。结论:阴道液肌酐水平检测是一种快速、简便、准确诊断ROM的检测方法。它具有很高的灵敏度、特异性、PPV和NPV。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vaginal Fluid Creatinine Levels to Detect Rupture of Membranes.

Introduction: When amniotic fluid leaks from the vagina, due to rupture of membranes (ROM) before uterine contractions begin, at a gestational age shorter than 37 weeks, the condition is known as preterm premature rupture of foetal membranes. ROM before the onset of labour, after 37 weeks, is known as pre-labour rupture of foetal membranes. Our study sought to examine whether vaginal fluid creatinine levels might be utilised to diagnose women with ROM.

Objectives: To study the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of vaginal fluid creatinine in diagnosis of rupture of membranes.

Methods: The study included 60 pregnant women with singleton pregnancy who were admitted to MVJMC & RH and met the inclusion criteria with gestational age between 28 and 40 weeks. This was a hospital-based prospective comparative study. The study group included 30 pregnant women who complained of vaginal fluid leak (case group) and 30 pregnant women without ROM, who were randomly enrolled from the labour room (control group). If obvious 'leaking' was present then 3 ml of vaginal fluid sample was collected with a syringe. If the membranes were intact then 5 ml of sterile saline solution was instilled into the posterior vaginal fornix and 3 ml of the fluid was withdrawn with same syringe, and sent for vaginal fluid creatinine level estimation.

Results: In case and control groups, the mean and standard deviations of vaginal fluid creatinine was 1.50 ± 0.25 mg/dL and 0.52 ± 0.28 mg/dL, respectively. The ideal cutoff score was established using the receiver operator characteristic (ROC) curve coordinates by balancing sensitivity and specificity. The cutoff score of 1.050 mg/dL was selected, with a 93.1% sensitivity rate, a 90.3% specificity rate, 90.0% PPV, and 93.3% NPV.

Conclusion: A quick, easy test that can accurately diagnose ROM, is the detection of creatinine levels in vaginal fluid. It has high sensitivity, specificity, PPV, and NPV.

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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
124
期刊介绍: Journal of Obstetrics and Gynecology of India (JOGI) is the official journal of the Federation of Obstetrics and Gynecology Societies of India (FOGSI). This is a peer- reviewed journal and features articles pertaining to the field of obstetrics and gynecology. The Journal is published six times a year on a bimonthly basis. Articles contributed by clinicians involved in patient care and research, and basic science researchers are considered. It publishes clinical and basic research of all aspects of obstetrics and gynecology, community obstetrics and family welfare and subspecialty subjects including gynecological endoscopy, infertility, oncology and ultrasonography, provided they have scientific merit and represent an important advance in knowledge. The journal believes in diversity and welcomes and encourages relevant contributions from world over. The types of articles published are: ·         Original Article·         Case Report ·         Instrumentation and Techniques ·         Short Commentary ·         Correspondence (Letter to the Editor) ·         Pictorial Essay
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