阿达木单抗在免疫失调引起的复发性妊娠丢失中的作用：一个病例系列报告。

IF 0.7 Q4 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynecology of India Pub Date : 2025-04-01 Epub Date: 2025-02-01 DOI:10.1007/s13224-024-02083-4

Aruna Rajan, S Ramakrishnan, Madhumitha, Mohini Sethi Kara, Jabacsmick Sharmila, Priyanka Raghunathan, Mangayarkarasi, Sofia Mercy

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引用次数: 0

摘要

肿瘤坏死因子- α是一种多功能t辅助1 （Th1）细胞因子，在胎盘和胚胎发育中起重要作用。TNF-α表达的改变与不良妊娠结局有关，如复发性妊娠丢失（RPL）和先兆子痫（PE）。TNF-α抑制剂（TNFi）如阿达木单抗（AD）的使用引起了人们的关注，因为它能够穿过胎盘屏障，并在怀孕期间调节母体免疫反应。在这篇文章中，我们讨论了两例在其他原因不明的RPL中发现免疫因素的患者，以及如何使用TNFi帮助实现可存活的妊娠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of Adalimumab in Recurrent Pregnancy Loss Due Immune Dysregulation: A Case Series Report.

Tumor necrosis factor-alpha, a multifunctional T-helper 1 (Th1) cytokine, plays a significant role in placentation and embryonic development. Altered expression of TNF-α has been implicated in adverse pregnancy outcomes such as recurrent pregnancy loss (RPL) and pre-eclampsia (PE). The use of TNF-α inhibitors (TNFi) like Adalimumab (AD) has garnered attention for its ability to traverse the placental barrier, and modulating maternal immune responses during pregnancy. In this article, we have discussed two patients in whom the immunological factors have been identified in otherwise unexplained RPL and how the use of TNFi could be of help to achieve a viable pregnancy.

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来源期刊

Journal of Obstetrics and Gynecology of India OBSTETRICS & GYNECOLOGY-

CiteScore

1.30

自引率

0.00%

发文量

124

期刊介绍： Journal of Obstetrics and Gynecology of India (JOGI) is the official journal of the Federation of Obstetrics and Gynecology Societies of India (FOGSI). This is a peer- reviewed journal and features articles pertaining to the field of obstetrics and gynecology. The Journal is published six times a year on a bimonthly basis. Articles contributed by clinicians involved in patient care and research, and basic science researchers are considered. It publishes clinical and basic research of all aspects of obstetrics and gynecology, community obstetrics and family welfare and subspecialty subjects including gynecological endoscopy, infertility, oncology and ultrasonography, provided they have scientific merit and represent an important advance in knowledge. The journal believes in diversity and welcomes and encourages relevant contributions from world over. The types of articles published are: · Original Article· Case Report · Instrumentation and Techniques · Short Commentary · Correspondence (Letter to the Editor) · Pictorial Essay