Anna Margarete Maria Thurner, Daniela Krepper, Sandra Nolte, Monika Sztankay, Maria Agthe, Johannes Maria Giesinger
{"title":"癌症特异性的性别差异和性别特异性的社会人口特征对癌症患者健康相关生活质量的影响：一项横断面研究","authors":"Anna Margarete Maria Thurner, Daniela Krepper, Sandra Nolte, Monika Sztankay, Maria Agthe, Johannes Maria Giesinger","doi":"10.1002/pon.70170","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Health-related quality of life (HRQoL) is a multi-dimensional concept commonly assessed in patient-centered research on the impact of cancer and its treatment. Apart from disease and treatment characteristics, HRQoL is also influenced by sociodemographic variables. However, detailed evaluations of the impact of sociodemographic variables on HRQoL are scarce. Therefore, our study aims to (1) examine whether the magnitude of sex differences in HRQoL differs between cancer patients and the general population and (2) investigate if there is a sex-specific association between sociodemographic characteristics and cancer patients' HRQoL scores.</p><p><strong>Methods: </strong>For this retrospective, cross-sectional study, we relied on two datasets, with one providing HRQoL data from Austrian cancer patients (N = 574) and another containing normative data from the Austrian general population (N = 1002). HRQoL was assessed using the EORTC QLQ-C30 questionnaire.</p><p><strong>Results: </strong>Sex differences in HRQoL were observed in both cancer patients and the general population, with the magnitude of observed sex differences varying between the two groups in two EORTC QLQ-C30 scales, that is, statistically significant differences were found for Nausea/Vomiting (p = 0.009) and Sleep Disturbances (p = 0.042). Analyzing sex differences in cancer patients with regard to in the association of sociodemographic variables with EORTC QLQ-C30 scales, we found the strength of certain associations to be sex-specific, including associations of living situation with physical (p = 0.001), role (p = 0.004), and social functioning (p = 0.011).</p><p><strong>Conclusion: </strong>Our findings indicate that most sex differences in cancer patients' HRQoL reflect sex differences that also occur in the general population and are therefore, not cancer-specific, which is essential for the interpretation of cancer patients' HRQoL data. Sex-specific differences may also be, in part, associated with the sex-specific impact of sociodemographic variables on cancer patients' HRQoL. Detailed analyses of HRQoL data, including reference data from the general population, may allow for a better understanding of sex-specific treatment needs.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 5","pages":"e70170"},"PeriodicalIF":3.5000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089010/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cancer-Specificity of Sex Differences and Sex-Specific Impact of Sociodemographic Characteristics in Cancer Patients' Health-Related Quality of Life: A Cross-Sectional Study.\",\"authors\":\"Anna Margarete Maria Thurner, Daniela Krepper, Sandra Nolte, Monika Sztankay, Maria Agthe, Johannes Maria Giesinger\",\"doi\":\"10.1002/pon.70170\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Health-related quality of life (HRQoL) is a multi-dimensional concept commonly assessed in patient-centered research on the impact of cancer and its treatment. Apart from disease and treatment characteristics, HRQoL is also influenced by sociodemographic variables. However, detailed evaluations of the impact of sociodemographic variables on HRQoL are scarce. Therefore, our study aims to (1) examine whether the magnitude of sex differences in HRQoL differs between cancer patients and the general population and (2) investigate if there is a sex-specific association between sociodemographic characteristics and cancer patients' HRQoL scores.</p><p><strong>Methods: </strong>For this retrospective, cross-sectional study, we relied on two datasets, with one providing HRQoL data from Austrian cancer patients (N = 574) and another containing normative data from the Austrian general population (N = 1002). HRQoL was assessed using the EORTC QLQ-C30 questionnaire.</p><p><strong>Results: </strong>Sex differences in HRQoL were observed in both cancer patients and the general population, with the magnitude of observed sex differences varying between the two groups in two EORTC QLQ-C30 scales, that is, statistically significant differences were found for Nausea/Vomiting (p = 0.009) and Sleep Disturbances (p = 0.042). Analyzing sex differences in cancer patients with regard to in the association of sociodemographic variables with EORTC QLQ-C30 scales, we found the strength of certain associations to be sex-specific, including associations of living situation with physical (p = 0.001), role (p = 0.004), and social functioning (p = 0.011).</p><p><strong>Conclusion: </strong>Our findings indicate that most sex differences in cancer patients' HRQoL reflect sex differences that also occur in the general population and are therefore, not cancer-specific, which is essential for the interpretation of cancer patients' HRQoL data. Sex-specific differences may also be, in part, associated with the sex-specific impact of sociodemographic variables on cancer patients' HRQoL. Detailed analyses of HRQoL data, including reference data from the general population, may allow for a better understanding of sex-specific treatment needs.</p>\",\"PeriodicalId\":20779,\"journal\":{\"name\":\"Psycho‐Oncology\",\"volume\":\"34 5\",\"pages\":\"e70170\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089010/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psycho‐Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/pon.70170\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psycho‐Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/pon.70170","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Cancer-Specificity of Sex Differences and Sex-Specific Impact of Sociodemographic Characteristics in Cancer Patients' Health-Related Quality of Life: A Cross-Sectional Study.
Background: Health-related quality of life (HRQoL) is a multi-dimensional concept commonly assessed in patient-centered research on the impact of cancer and its treatment. Apart from disease and treatment characteristics, HRQoL is also influenced by sociodemographic variables. However, detailed evaluations of the impact of sociodemographic variables on HRQoL are scarce. Therefore, our study aims to (1) examine whether the magnitude of sex differences in HRQoL differs between cancer patients and the general population and (2) investigate if there is a sex-specific association between sociodemographic characteristics and cancer patients' HRQoL scores.
Methods: For this retrospective, cross-sectional study, we relied on two datasets, with one providing HRQoL data from Austrian cancer patients (N = 574) and another containing normative data from the Austrian general population (N = 1002). HRQoL was assessed using the EORTC QLQ-C30 questionnaire.
Results: Sex differences in HRQoL were observed in both cancer patients and the general population, with the magnitude of observed sex differences varying between the two groups in two EORTC QLQ-C30 scales, that is, statistically significant differences were found for Nausea/Vomiting (p = 0.009) and Sleep Disturbances (p = 0.042). Analyzing sex differences in cancer patients with regard to in the association of sociodemographic variables with EORTC QLQ-C30 scales, we found the strength of certain associations to be sex-specific, including associations of living situation with physical (p = 0.001), role (p = 0.004), and social functioning (p = 0.011).
Conclusion: Our findings indicate that most sex differences in cancer patients' HRQoL reflect sex differences that also occur in the general population and are therefore, not cancer-specific, which is essential for the interpretation of cancer patients' HRQoL data. Sex-specific differences may also be, in part, associated with the sex-specific impact of sociodemographic variables on cancer patients' HRQoL. Detailed analyses of HRQoL data, including reference data from the general population, may allow for a better understanding of sex-specific treatment needs.
期刊介绍：
Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology.
This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues.
Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.
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