抗菌药物暂停计划对住院患者抗菌药物消费率的影响:伊朗国家抗菌药物管理计划的准实验研究:伊朗抗菌药物管理计划。

IF 1.2 Q4 PHARMACOLOGY & PHARMACY
Mohammadreza Salehi, Marzieh Arabi, Hossein Khalili, Yunes Panahi, Erta Rajabi, Esmaeil Mohammadnejad, Amir-Mohammad Yaryari, Arash Seifi, Mitra Barati, Kousha Farhadi
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引用次数: 0

摘要

背景:本研究评估了国家抗菌药物管理计划(NASP)对抗菌药物消费的影响。方法:对伊朗德黑兰一家转诊医院的住院患者进行准实验研究。我们比较了2022年第三季度(在2022年10月COVID-19大流行后实施NASP之前)和2023年NASP实施后的同一时间段内的抗菌药物定义日剂量(DDD)和抗菌药物消耗指数(ACI)。NASP基于抗菌时间评估。在处方美罗培南、亚胺培南、利奈唑胺、万古霉素、伏立康唑、卡泊芬净和两性霉素B脂质体的72小时内,传染病专家审核患者的临床和微生物证据,以评估其是否符合正确的处方。结果:对2022年第三季度13794例住院患者和2023年第三季度15030例住院患者抗菌药物消费率进行了评估。平均住院时间和死亡率无显著差异。所有受限制的抗菌素的消耗量都下降了。亚胺培南、卡泊芬金、万古霉素和利奈唑胺的这种降低是显著的。实施NASP后,抗菌药物总费用降低22.24% (P = 0.01)。结论:抗菌暂停计划与减少抗菌剂(包括亚胺培南、利奈唑胺、万古霉素)和抗真菌剂(如卡泊芬净)的使用有关,而不增加住院时间和死亡率。NASP的实施可以推荐为减少广谱抗菌素使用的有益方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of an antimicrobial time-out program on antimicrobial consumption rate in hospitalized patients: a quasi-experimental study on the national antimicrobial stewardship program in Iran : Iranian antimicrobial stewardship program.

Background: This study evaluated the impact of the national antimicrobial stewardship program (NASP) on the consumption of antimicrobial agents.

Methods: A quasi-experimental study was conducted on hospitalized patients at a referral hospital in Tehran, Iran. We compared the antimicrobial-defined daily dose (DDD) and antimicrobial consumption index (ACI) between the third quarter of 2022 (before the implementation of NASP after the COVID-19 pandemic in October 2022) and the same timeframe in 2023, following the NASP implementation. The NASP was based on antimicrobial time-out assessment. Within 72 h of prescribing meropenem, imipenem, linezolid, vancomycin, voriconazole, caspofungin, and amphotericin B liposomal, infectious disease specialists audited the clinical and microbiological evidence of patients to assess whether it was consistent with the correct prescription.

Results: The antimicrobial consumption rate was assessed in 13,794 and 15,030 hospitalized patients during the third quarter of 2022 and the third quarter of 2023, respectively. The mean length of hospital stay and mortality rate showed no significant differences. The consumption of all restricted antimicrobials decreased. This reduction was significant for imipenem, caspofungin, vancomycin, and linezolid. The total cost of antimicrobial agents had a 22.24% reduction after the NASP implementation (P = 0.01).

Conclusions: The antimicrobial time-out program was associated with a reduction in the use of antimicrobials, including imipenem, linezolid, and vancomycin and antifungals, such as caspofungin without increasing the length of stay and mortality rate. The NASP implementation can be recommended as a beneficial method for reducing the use of broad-spectrum antimicrobials.

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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
29
审稿时长
8 weeks
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