Shwe Sin Win, Gerhard Sulo, Anders Engeland, Kari Klungsøyr
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The Norwegian Patient Registry and the Norwegian Prescription Database were used to define study exposures: history of hypertension, diabetes, dyslipidaemia, severe obesity or any of these at any time before/during the year of childbirth while fathers having no such conditions were the reference group. Perinatal mortality was defined as foetal death from 16 weeks' gestation or neonatal deaths within the first month after birth (from the MBRN). We fitted multilevel random-intercept Poisson regression models to account for the clustering of infants born to the same father. We reported incidence rate ratio (IRR) with 95% confidence Intervals (CI).</p><p><strong>Results: </strong>Of 703,746 infants, 3.6% (n = 25,314) were born to fathers with any condition. Overall, 4827 (0.7%) of them died perinatally. In fully adjusted models, infants of fathers with hypertension had a 29% higher risk of dying perinatally (IRR 1.29, 95% CI 1.05, 1.57) relative to those of fathers without cardiometabolic conditions. Effect estimates for paternal diabetes, severe obesity and any condition also indicated a possible increased perinatal mortality associated with these conditions. In the sex-stratified analysis, the associations were stronger in male offspring (IRR 1.29, 95% CI 1.06, 1.58) than female offspring (IRR 1.01, 95% CI 0.78, 1.29).</p><p><strong>Conclusions: </strong>The increased perinatal mortality in offspring to fathers with cardiometabolic conditions emphasises fathers' biological role in foetal and placental programming and development. Whether offspring sex impacts these associations needs further investigation.</p>","PeriodicalId":19698,"journal":{"name":"Paediatric and perinatal epidemiology","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Paternal Cardiometabolic Conditions and Perinatal Mortality.\",\"authors\":\"Shwe Sin Win, Gerhard Sulo, Anders Engeland, Kari Klungsøyr\",\"doi\":\"10.1111/ppe.70032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Studies have suggested that men with cardiometabolic conditions may have an increased risk of offspring perinatal mortality. However, this association remains underexplored.</p><p><strong>Objectives: </strong>We aimed to study the association between fathers' cardiometabolic conditions and offspring perinatal mortality utilising linked data from national health registries in Norway.</p><p><strong>Methods: </strong>In this population-based cohort study, males registered in the Medical Birth Registry of Norway (MBRN), born 1967-2005, were linked to their singleton offsprings born 2004-2020. The Norwegian Patient Registry and the Norwegian Prescription Database were used to define study exposures: history of hypertension, diabetes, dyslipidaemia, severe obesity or any of these at any time before/during the year of childbirth while fathers having no such conditions were the reference group. Perinatal mortality was defined as foetal death from 16 weeks' gestation or neonatal deaths within the first month after birth (from the MBRN). We fitted multilevel random-intercept Poisson regression models to account for the clustering of infants born to the same father. We reported incidence rate ratio (IRR) with 95% confidence Intervals (CI).</p><p><strong>Results: </strong>Of 703,746 infants, 3.6% (n = 25,314) were born to fathers with any condition. Overall, 4827 (0.7%) of them died perinatally. In fully adjusted models, infants of fathers with hypertension had a 29% higher risk of dying perinatally (IRR 1.29, 95% CI 1.05, 1.57) relative to those of fathers without cardiometabolic conditions. Effect estimates for paternal diabetes, severe obesity and any condition also indicated a possible increased perinatal mortality associated with these conditions. In the sex-stratified analysis, the associations were stronger in male offspring (IRR 1.29, 95% CI 1.06, 1.58) than female offspring (IRR 1.01, 95% CI 0.78, 1.29).</p><p><strong>Conclusions: </strong>The increased perinatal mortality in offspring to fathers with cardiometabolic conditions emphasises fathers' biological role in foetal and placental programming and development. 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引用次数: 0
摘要
背景:研究表明,患有心脏代谢疾病的男性可能会增加后代围产期死亡的风险。然而,这种联系仍未得到充分探讨。目的:我们旨在利用挪威国家卫生登记的相关数据研究父亲心脏代谢状况与后代围产期死亡率之间的关系。方法:在这项基于人群的队列研究中,在挪威医学出生登记处(MBRN)登记的1967-2005年出生的男性与其2004-2020年出生的单胎后代相关联。挪威患者登记处和挪威处方数据库被用来定义研究暴露:高血压、糖尿病、血脂异常、严重肥胖或在分娩前/分娩期间的任何时间的任何这些病史,而没有这些疾病的父亲是参照组。围产期死亡率的定义是妊娠16周以上的胎儿死亡或出生后第一个月内的新生儿死亡(来自MBRN)。我们拟合了多水平随机截距泊松回归模型,以解释同一父亲所生婴儿的聚类。我们以95%可信区间(CI)报告发病率比(IRR)。结果:在703,746名婴儿中,3.6% (n = 25,314)的父亲有任何疾病。其中4827例(0.7%)死亡。在完全调整后的模型中,父亲患有高血压的婴儿的围产期死亡风险比父亲没有心脏代谢疾病的婴儿高29% (IRR 1.29, 95% CI 1.05, 1.57)。对父亲糖尿病、严重肥胖和任何疾病的影响估计也表明,与这些疾病相关的围产期死亡率可能增加。在性别分层分析中,男性后代的相关性(IRR 1.29, 95% CI 1.06, 1.58)强于女性后代(IRR 1.01, 95% CI 0.78, 1.29)。结论:患有心脏代谢疾病的父亲的后代围产期死亡率增加,强调了父亲在胎儿和胎盘规划和发育中的生物学作用。后代性别是否会影响这些关联还需要进一步研究。
Paternal Cardiometabolic Conditions and Perinatal Mortality.
Background: Studies have suggested that men with cardiometabolic conditions may have an increased risk of offspring perinatal mortality. However, this association remains underexplored.
Objectives: We aimed to study the association between fathers' cardiometabolic conditions and offspring perinatal mortality utilising linked data from national health registries in Norway.
Methods: In this population-based cohort study, males registered in the Medical Birth Registry of Norway (MBRN), born 1967-2005, were linked to their singleton offsprings born 2004-2020. The Norwegian Patient Registry and the Norwegian Prescription Database were used to define study exposures: history of hypertension, diabetes, dyslipidaemia, severe obesity or any of these at any time before/during the year of childbirth while fathers having no such conditions were the reference group. Perinatal mortality was defined as foetal death from 16 weeks' gestation or neonatal deaths within the first month after birth (from the MBRN). We fitted multilevel random-intercept Poisson regression models to account for the clustering of infants born to the same father. We reported incidence rate ratio (IRR) with 95% confidence Intervals (CI).
Results: Of 703,746 infants, 3.6% (n = 25,314) were born to fathers with any condition. Overall, 4827 (0.7%) of them died perinatally. In fully adjusted models, infants of fathers with hypertension had a 29% higher risk of dying perinatally (IRR 1.29, 95% CI 1.05, 1.57) relative to those of fathers without cardiometabolic conditions. Effect estimates for paternal diabetes, severe obesity and any condition also indicated a possible increased perinatal mortality associated with these conditions. In the sex-stratified analysis, the associations were stronger in male offspring (IRR 1.29, 95% CI 1.06, 1.58) than female offspring (IRR 1.01, 95% CI 0.78, 1.29).
Conclusions: The increased perinatal mortality in offspring to fathers with cardiometabolic conditions emphasises fathers' biological role in foetal and placental programming and development. Whether offspring sex impacts these associations needs further investigation.
期刊介绍:
Paediatric and Perinatal Epidemiology crosses the boundaries between the epidemiologist and the paediatrician, obstetrician or specialist in child health, ensuring that important paediatric and perinatal studies reach those clinicians for whom the results are especially relevant. In addition to original research articles, the Journal also includes commentaries, book reviews and annotations.