Bassant M M Ibrahim, A F Yousuf, M M El-Shawwa, Mona A Mohammed
{"title":"甘草、乳香和尼罗金合欢治疗急性过敏性皮炎的药物代谢组学研究。","authors":"Bassant M M Ibrahim, A F Yousuf, M M El-Shawwa, Mona A Mohammed","doi":"10.1007/s10787-025-01761-7","DOIUrl":null,"url":null,"abstract":"<p><p>Acute allergic contact dermatitis is an inflammatory skin condition characterized by swollen, itchy lesions. This study aimed to evaluate the soothing and wound-healing effects of fixed and volatile oils of Boswellia sarca, as well as extracts of Glycyrrhiza glabra and Acacia nilotica, on acute contact dermatitis in rats. Phytochemical analysis revealed the presence of flavonoids, tannins, saponins, triterpenoids, alkaloids, and cardiac glycosides in Acacia nilotica and, Glycyrrhiza glabra extracts, with Boswellia sarca showing a dominance of volatile oils. The study included a normal group and six acute allergic dermatitis groups induced by subcutaneous histamine injection. One group served as a positive control without treatment, while five groups were treated topically at inflamed sites with Boswellia sarca oils, Glycyrrhiza glabra, and Acacia nilotica extracts, alongside betamethasone as a standard treatment. The effects were evaluated through inspection, serum levels of ICAM-1, LTB4, and ILβ-4, as well as histopathological and immunohistochemical analyses. GC/MS analysis identified Incensole acetate (50.12%) and Incensole (32.44%) as major compounds in BS fixed oil, with significant terpenoids and volatile components. Metabolomic profiling using LC-MS/MS highlighted diverse secondary metabolites in Acacia nilotica and, Glycyrrhiza glabra, including polyphenolic acids, flavonoids, and amino acids, showcasing their therapeutic potential. All topical treatments reduced ICAM-1 and LTB4 levels to varying degrees and exhibited better histopathological and immunohistochemical results compared to the untreated positive control group. Among the treatments, Boswellia oils and, Glycyrrhiza glabra extracts demonstrated the most effective soothing and curative effects on allergic dermatitis. Boswellia sarca oils and, Glycyrrhiza glabra extract showed the best soothing and curative effects against allergic dermatitis.</p>","PeriodicalId":13551,"journal":{"name":"Inflammopharmacology","volume":" ","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A pharmaco-metabolomics study of Glycyrrhiza glabra, Boswellia sarca, and Acacia nilotica in acute allergic dermatitis.\",\"authors\":\"Bassant M M Ibrahim, A F Yousuf, M M El-Shawwa, Mona A Mohammed\",\"doi\":\"10.1007/s10787-025-01761-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Acute allergic contact dermatitis is an inflammatory skin condition characterized by swollen, itchy lesions. This study aimed to evaluate the soothing and wound-healing effects of fixed and volatile oils of Boswellia sarca, as well as extracts of Glycyrrhiza glabra and Acacia nilotica, on acute contact dermatitis in rats. Phytochemical analysis revealed the presence of flavonoids, tannins, saponins, triterpenoids, alkaloids, and cardiac glycosides in Acacia nilotica and, Glycyrrhiza glabra extracts, with Boswellia sarca showing a dominance of volatile oils. The study included a normal group and six acute allergic dermatitis groups induced by subcutaneous histamine injection. One group served as a positive control without treatment, while five groups were treated topically at inflamed sites with Boswellia sarca oils, Glycyrrhiza glabra, and Acacia nilotica extracts, alongside betamethasone as a standard treatment. The effects were evaluated through inspection, serum levels of ICAM-1, LTB4, and ILβ-4, as well as histopathological and immunohistochemical analyses. GC/MS analysis identified Incensole acetate (50.12%) and Incensole (32.44%) as major compounds in BS fixed oil, with significant terpenoids and volatile components. Metabolomic profiling using LC-MS/MS highlighted diverse secondary metabolites in Acacia nilotica and, Glycyrrhiza glabra, including polyphenolic acids, flavonoids, and amino acids, showcasing their therapeutic potential. All topical treatments reduced ICAM-1 and LTB4 levels to varying degrees and exhibited better histopathological and immunohistochemical results compared to the untreated positive control group. Among the treatments, Boswellia oils and, Glycyrrhiza glabra extracts demonstrated the most effective soothing and curative effects on allergic dermatitis. 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A pharmaco-metabolomics study of Glycyrrhiza glabra, Boswellia sarca, and Acacia nilotica in acute allergic dermatitis.
Acute allergic contact dermatitis is an inflammatory skin condition characterized by swollen, itchy lesions. This study aimed to evaluate the soothing and wound-healing effects of fixed and volatile oils of Boswellia sarca, as well as extracts of Glycyrrhiza glabra and Acacia nilotica, on acute contact dermatitis in rats. Phytochemical analysis revealed the presence of flavonoids, tannins, saponins, triterpenoids, alkaloids, and cardiac glycosides in Acacia nilotica and, Glycyrrhiza glabra extracts, with Boswellia sarca showing a dominance of volatile oils. The study included a normal group and six acute allergic dermatitis groups induced by subcutaneous histamine injection. One group served as a positive control without treatment, while five groups were treated topically at inflamed sites with Boswellia sarca oils, Glycyrrhiza glabra, and Acacia nilotica extracts, alongside betamethasone as a standard treatment. The effects were evaluated through inspection, serum levels of ICAM-1, LTB4, and ILβ-4, as well as histopathological and immunohistochemical analyses. GC/MS analysis identified Incensole acetate (50.12%) and Incensole (32.44%) as major compounds in BS fixed oil, with significant terpenoids and volatile components. Metabolomic profiling using LC-MS/MS highlighted diverse secondary metabolites in Acacia nilotica and, Glycyrrhiza glabra, including polyphenolic acids, flavonoids, and amino acids, showcasing their therapeutic potential. All topical treatments reduced ICAM-1 and LTB4 levels to varying degrees and exhibited better histopathological and immunohistochemical results compared to the untreated positive control group. Among the treatments, Boswellia oils and, Glycyrrhiza glabra extracts demonstrated the most effective soothing and curative effects on allergic dermatitis. Boswellia sarca oils and, Glycyrrhiza glabra extract showed the best soothing and curative effects against allergic dermatitis.
期刊介绍：
Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas:
-Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states
-Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs
-Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents
-Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain
-Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs
-Muscle-immune interactions during inflammation [...]
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