Alberto Scarselli, Antonietta Porzio, Alessandro Marinaccio
{"title":"使用基于登记的信息系统评估丙烯腈暴露工人队列的职业暴露风险。","authors":"Alberto Scarselli, Antonietta Porzio, Alessandro Marinaccio","doi":"10.1093/annweh/wxaf021","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to explore the extent of exposure to acrylonitrile in workplaces in Italy and its potential implications for workers' health.</p><p><strong>Methods: </strong>Exposure measurements data (n = 31,599) on acrylonitrile reported in the period 1996 to 2022 to the Italian national register of occupational exposures, called SIREP, were collected and analysed. Concurrent exposures with other occupational carcinogens were investigated using SPSS 2-step cluster analysis. A retrospective register-based cohort mortality study was performed, and standardized mortality ratios (SMRs) were calculated linking exposure data to national mortality statistics in the period 2005 to 2020.</p><p><strong>Results: </strong>Most of the exposures occurred in the chemical industry (88%). Exposure to multiple occupational carcinogens was detected frequently (92% of exposed workers). Elevated proportions of deaths from lung and brain cancer, as well as Parkinson's disease, were found among exposed male workers (SMR = 1.3, CI: 1.0 to 1.7; SMR = 1.8, CI: 1.0 to 3.2; and SMR = 2.8, CI: 1.2 to 6.8, respectively). Among other cancers, increased proportions of deaths from multiple myeloma (SMR = 2.9, CI: 1.4 to 5.7), leukemia (SMR = 3.7, CI:1.2 to 11.4), and mesothelioma (SMR = 4.2, CI: 2.2 to 8.1) were also found.</p><p><strong>Conclusions: </strong>The monitoring of occupational exposures for the prevention of related risks is the main goal of epidemiological surveillance systems such as SIREP. Some acrylonitrile exposure circumstances deserve special attention, especially in the chemical and plastic industries. The excesses mortality from Parkinson's disease, lung cancer, and brain cancer constitute an actual concern for acrylonitrile exposed workers and warrant the implementation of further prevention measures and investigation.</p>","PeriodicalId":8362,"journal":{"name":"Annals Of Work Exposures and Health","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of occupational exposure risk experienced by a cohort of workers exposed to acrylonitrile using a register-based information system.\",\"authors\":\"Alberto Scarselli, Antonietta Porzio, Alessandro Marinaccio\",\"doi\":\"10.1093/annweh/wxaf021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aims to explore the extent of exposure to acrylonitrile in workplaces in Italy and its potential implications for workers' health.</p><p><strong>Methods: </strong>Exposure measurements data (n = 31,599) on acrylonitrile reported in the period 1996 to 2022 to the Italian national register of occupational exposures, called SIREP, were collected and analysed. Concurrent exposures with other occupational carcinogens were investigated using SPSS 2-step cluster analysis. A retrospective register-based cohort mortality study was performed, and standardized mortality ratios (SMRs) were calculated linking exposure data to national mortality statistics in the period 2005 to 2020.</p><p><strong>Results: </strong>Most of the exposures occurred in the chemical industry (88%). Exposure to multiple occupational carcinogens was detected frequently (92% of exposed workers). Elevated proportions of deaths from lung and brain cancer, as well as Parkinson's disease, were found among exposed male workers (SMR = 1.3, CI: 1.0 to 1.7; SMR = 1.8, CI: 1.0 to 3.2; and SMR = 2.8, CI: 1.2 to 6.8, respectively). Among other cancers, increased proportions of deaths from multiple myeloma (SMR = 2.9, CI: 1.4 to 5.7), leukemia (SMR = 3.7, CI:1.2 to 11.4), and mesothelioma (SMR = 4.2, CI: 2.2 to 8.1) were also found.</p><p><strong>Conclusions: </strong>The monitoring of occupational exposures for the prevention of related risks is the main goal of epidemiological surveillance systems such as SIREP. Some acrylonitrile exposure circumstances deserve special attention, especially in the chemical and plastic industries. The excesses mortality from Parkinson's disease, lung cancer, and brain cancer constitute an actual concern for acrylonitrile exposed workers and warrant the implementation of further prevention measures and investigation.</p>\",\"PeriodicalId\":8362,\"journal\":{\"name\":\"Annals Of Work Exposures and Health\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals Of Work Exposures and Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/annweh/wxaf021\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals Of Work Exposures and Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/annweh/wxaf021","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Evaluation of occupational exposure risk experienced by a cohort of workers exposed to acrylonitrile using a register-based information system.
Objectives: This study aims to explore the extent of exposure to acrylonitrile in workplaces in Italy and its potential implications for workers' health.
Methods: Exposure measurements data (n = 31,599) on acrylonitrile reported in the period 1996 to 2022 to the Italian national register of occupational exposures, called SIREP, were collected and analysed. Concurrent exposures with other occupational carcinogens were investigated using SPSS 2-step cluster analysis. A retrospective register-based cohort mortality study was performed, and standardized mortality ratios (SMRs) were calculated linking exposure data to national mortality statistics in the period 2005 to 2020.
Results: Most of the exposures occurred in the chemical industry (88%). Exposure to multiple occupational carcinogens was detected frequently (92% of exposed workers). Elevated proportions of deaths from lung and brain cancer, as well as Parkinson's disease, were found among exposed male workers (SMR = 1.3, CI: 1.0 to 1.7; SMR = 1.8, CI: 1.0 to 3.2; and SMR = 2.8, CI: 1.2 to 6.8, respectively). Among other cancers, increased proportions of deaths from multiple myeloma (SMR = 2.9, CI: 1.4 to 5.7), leukemia (SMR = 3.7, CI:1.2 to 11.4), and mesothelioma (SMR = 4.2, CI: 2.2 to 8.1) were also found.
Conclusions: The monitoring of occupational exposures for the prevention of related risks is the main goal of epidemiological surveillance systems such as SIREP. Some acrylonitrile exposure circumstances deserve special attention, especially in the chemical and plastic industries. The excesses mortality from Parkinson's disease, lung cancer, and brain cancer constitute an actual concern for acrylonitrile exposed workers and warrant the implementation of further prevention measures and investigation.
期刊介绍:
About the Journal
Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?"
We are interested in high quality scientific research addressing:
the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures;
the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities;
populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers;
the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems;
policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities;
methodologies and mechanisms that underlie the quantification and/or control of exposure and risk.
There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.