使用基于登记的信息系统评估丙烯腈暴露工人队列的职业暴露风险。

IF 1.8 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Alberto Scarselli, Antonietta Porzio, Alessandro Marinaccio
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引用次数: 0

摘要

目的:本研究旨在探讨意大利工作场所暴露于丙烯腈的程度及其对工人健康的潜在影响。方法:收集和分析1996年至2022年期间向意大利国家职业暴露登记册(SIREP)报告的丙烯腈暴露测量数据(n = 31,599)。使用SPSS两步聚类分析调查与其他职业致癌物同时暴露的情况。进行了一项基于登记的回顾性队列死亡率研究,并计算了标准化死亡率(SMRs),将2005年至2020年期间的暴露数据与国家死亡率统计数据联系起来。结果:以化学工业暴露最多(88%)。经常检测到暴露于多种职业致癌物(92%的暴露工人)。暴露的男性工人死于肺癌和脑癌以及帕金森病的比例升高(SMR = 1.3, CI: 1.0至1.7;SMR = 1.8, CI: 1.0 ~ 3.2;SMR = 2.8, CI分别为1.2 ~ 6.8)。在其他癌症中,多发性骨髓瘤(SMR = 2.9, CI: 1.4至5.7)、白血病(SMR = 3.7, CI:1.2至11.4)和间皮瘤(SMR = 4.2, CI: 2.2至8.1)的死亡比例也有所增加。结论:监测职业暴露,预防相关风险是SIREP等流行病学监测系统的主要目标。一些丙烯腈暴露情况值得特别注意,特别是在化学和塑料工业中。帕金森氏症、肺癌和脑癌的高死亡率对接触丙烯腈的工人构成了实际关注,需要采取进一步的预防措施和调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of occupational exposure risk experienced by a cohort of workers exposed to acrylonitrile using a register-based information system.

Objectives: This study aims to explore the extent of exposure to acrylonitrile in workplaces in Italy and its potential implications for workers' health.

Methods: Exposure measurements data (n = 31,599) on acrylonitrile reported in the period 1996 to 2022 to the Italian national register of occupational exposures, called SIREP, were collected and analysed. Concurrent exposures with other occupational carcinogens were investigated using SPSS 2-step cluster analysis. A retrospective register-based cohort mortality study was performed, and standardized mortality ratios (SMRs) were calculated linking exposure data to national mortality statistics in the period 2005 to 2020.

Results: Most of the exposures occurred in the chemical industry (88%). Exposure to multiple occupational carcinogens was detected frequently (92% of exposed workers). Elevated proportions of deaths from lung and brain cancer, as well as Parkinson's disease, were found among exposed male workers (SMR = 1.3, CI: 1.0 to 1.7; SMR = 1.8, CI: 1.0 to 3.2; and SMR = 2.8, CI: 1.2 to 6.8, respectively). Among other cancers, increased proportions of deaths from multiple myeloma (SMR = 2.9, CI: 1.4 to 5.7), leukemia (SMR = 3.7, CI:1.2 to 11.4), and mesothelioma (SMR = 4.2, CI: 2.2 to 8.1) were also found.

Conclusions: The monitoring of occupational exposures for the prevention of related risks is the main goal of epidemiological surveillance systems such as SIREP. Some acrylonitrile exposure circumstances deserve special attention, especially in the chemical and plastic industries. The excesses mortality from Parkinson's disease, lung cancer, and brain cancer constitute an actual concern for acrylonitrile exposed workers and warrant the implementation of further prevention measures and investigation.

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来源期刊
Annals Of Work Exposures and Health
Annals Of Work Exposures and Health Medicine-Public Health, Environmental and Occupational Health
CiteScore
4.60
自引率
19.20%
发文量
79
期刊介绍: About the Journal Annals of Work Exposures and Health is dedicated to presenting advances in exposure science supporting the recognition, quantification, and control of exposures at work, and epidemiological studies on their effects on human health and well-being. A key question we apply to submission is, "Is this paper going to help readers better understand, quantify, and control conditions at work that adversely or positively affect health and well-being?" We are interested in high quality scientific research addressing: the quantification of work exposures, including chemical, biological, physical, biomechanical, and psychosocial, and the elements of work organization giving rise to such exposures; the relationship between these exposures and the acute and chronic health consequences for those exposed and their families and communities; populations at special risk of work-related exposures including women, under-represented minorities, immigrants, and other vulnerable groups such as temporary, contingent and informal sector workers; the effectiveness of interventions addressing exposure and risk including production technologies, work process engineering, and personal protective systems; policies and management approaches to reduce risk and improve health and well-being among workers, their families or communities; methodologies and mechanisms that underlie the quantification and/or control of exposure and risk. There is heavy pressure on space in the journal, and the above interests mean that we do not usually publish papers that simply report local conditions without generalizable results. We are also unlikely to publish reports on human health and well-being without information on the work exposure characteristics giving rise to the effects. We particularly welcome contributions from scientists based in, or addressing conditions in, developing economies that fall within the above scope.
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