可见光诱导非活化萘的1,4-氨基甲酰吡啶脱芳化反应。

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-05-20 DOI:10.1039/d5ob00550g

Cheng-An Jin, Hao Liu, Bo-Wen Xie, Ren-Xiao Liang, Yi-Xia Jia

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引用次数: 0

摘要

描述了一种可见光诱导的非活性萘的1,4-氨基甲酰吡啶脱芳化反应。该方案以萘取代的肟酸和4-氰吡啶为底物，通过自由基-自由基交叉偶联，然后进行碱介导的烯烃互变异构化，以中等产量快速获得一系列吡啶化的螺1,2-二氢萘。此外，该方法还实现了几种药物衍生物的后期功能化，证明了该反应的实用性。

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Visible-light-induced dearomative 1,4-carbamoylpyridinylation of nonactivated naphthalenes.

A visible-light-induced dearomative 1,4-carbamoylpyridinylation of nonactivated naphthalenes is described. The protocol provides rapid access to a series of pyridinylated spiro 1,2-dihydronaphthalenes in moderate yields by using naphthyl-substituted oxamic acids and 4-cyanopyridines as substrates through radical-radical cross-coupling followed by base-mediated alkene tautomerization. In addition, this method enabled late-stage functionalization of several drug derivatives, demonstrating the practical utility of this reaction.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.