细菌血流感染中出现的抗生素耐药性:加纳Nkawkaw圣家医院的一项临床研究

IF 3.4 3区 医学 Q2 INFECTIOUS DISEASES
John Gameli Deku, Israel Bedzina, Prince Kwadade Amankwah, Lilian Kekeli Antor, Kenneth Ablordey, Madrid Alhassan, Akatwum Emmanuel Salifu, Robert Awupoli, Arnold Togiwe Luuse, Enoch Aninagyei, Innocent Afeke, Kwabena Obeng Duedu
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引用次数: 0

摘要

背景:菌血症是由各种细菌病原体引起的一种严重的血液感染,对健康构成重大挑战,特别是在抗生素耐药性加剧的情况下。目前的这项研究确定了加纳Nkawkaw圣家医院血液细菌分离株的流行情况及其抗生素耐药模式,时间跨度为6年。方法:开展了一项以医院为基础的回顾性研究,回顾了2018年至2023年在圣家医院就诊的患者中血液感染的细菌分离株及其抗生素耐药模式的记录。数据收集到Excel表格版本2021,清理,并导出到相应的统计软件,SPSS v26进行统计分析。p值小于0.05被认为在所有分析中具有统计学意义。结果:本组3228例病例中,年龄在1岁以下的占66.0%,1 ~ 10岁的占18.6%。菌血症患病率为8.7% (95% CI: 7.8-9.7%)。克雷伯氏菌最多,占30.2%,其次是金黄色葡萄球菌(26.0%)。抗生素耐药性最高的是四环素(94.5%)、青霉素(92.3%)和氯霉素(90.9%)。此外,对万古霉素(88.3%)、头孢呋辛(86.5%)和氯西林(84.4%)也有显著耐药。相反,阿米卡星的易感率最高(90.5%),其次是环丙沙星(75.0%)。结论:该研究强调了菌血症造成的重大公共卫生负担以及抗生素耐药性日益严峻的挑战。菌血症的流行,特别是由革兰氏阴性菌(如克雷伯氏菌和大肠杆菌)引起的,强调需要采取有针对性的干预措施,以改善卫生保健机构的感染控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging antibiotic resistance in bacterial bloodstream infections: a clinical study at the Holy Family Hospital, Nkawkaw, Ghana.

Background: Bacteraemia, a critical bloodstream infection caused by various bacterial pathogens, poses significant health challenges, particularly when compounded by antibiotic resistance. This current study determined the prevalence of bloodstream bacterial isolates and their antibiotic-resistant patterns at the Holy Family Hospital, Nkawkaw, Ghana, spanning a six-year period.

Methodology: A hospital-based retrospective study was carried out to review records of bacterial isolates of bloodstream infections and their antibiotic-resistant pattern among patients who visited the Holy Family Hospital between 2018 and 2023. The data was collected into an Excel sheet version 2021, cleaned, and exported to the appropriate statistical software, SPSS v26 for statistical analysis. A P-value less than 0.05 was considered statistically significant for all analyses.

Results: Of 3,228 records in this study, the majority (66.0%) were found to be under 1 year of age, while 18.6% were aged 1-10 years. The prevalence of bacteraemia was 8.7% (95% CI: 7.8-9.7%). Klebsiella species was found to be the most prevalent at 30.2%, followed by S. aureus (26.0%). The highest levels of antibiotic resistance were detected against tetracycline (94.5%), penicillin (92.3%), and chloramphenicol (90.9%). Also, significant resistance was also found against vancomycin (88.3%), cefuroxime (86.5%), and cloxacillin (84.4%). Conversely, amikacin demonstrated the highest susceptibility rate (90.5%), followed by ciprofloxacin (75.0%).

Conclusion: The study highlights the significant public health burden posed by bacteraemia and the growing challenge of antibiotic resistance. The prevalence of bacteraemia, particularly caused by Gram-negative organisms such as Klebsiella species and E. coli underscores the need for targeted interventions to improve infection control in healthcare settings.

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来源期刊
BMC Infectious Diseases
BMC Infectious Diseases 医学-传染病学
CiteScore
6.50
自引率
0.00%
发文量
860
审稿时长
3.3 months
期刊介绍: BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.
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