{"title":"抗衰落响应的稳定局部H2纳米发生器。","authors":"Jiaying Cao, Mingwei Zhong, Siyu Wang, Qibin Li, Wei Ma, Xiaodong Yan, Jing Wang, Yuan Zhao","doi":"10.1021/acsabm.5c00533","DOIUrl":null,"url":null,"abstract":"<p><p>Persistent inflammation effects existed in the senescence microenvironment, and hydrogen (H<sub>2</sub>) was an antioxidant stress agent and could solve the aging and inflammation. In view of the issue of low solubility of H<sub>2</sub> and conversion efficiency of traditional hydrogen therapy, an in-site hydrogen production system (HPS) was designed by using liposome as a compartment, emodin as a photosensitizer, l-ascorbic acid-2-phosphate trisodium salt (AAP) as hydrogen sources, and Au NPs as photocatalysts. Different from the commonly used chlorophyll A, emodin with strong absorption in the wide range of 200-500 nm could absorb more photons to form electrons for the participation of H<sub>2</sub> generation. Emodin- and AAP-embedded HPS largely increased stability at 50 °C for 28 days. HPS facilitated the decrease of inflammatory factors of TNF-α, IL-6, and ROS in RAW264.7 cells, as well as the elimination of senescence-associated β-galactosidase, realizing convenient and efficient antifading responses. But strikingly, the constructed HPS can penetrate the pig skin in transdermal experiments and showed huge prospects for the application of antifading cosmetics.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5205-5214"},"PeriodicalIF":4.7000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Stable and Local H<sub>2</sub> Nanogenerator for Antifading Responses.\",\"authors\":\"Jiaying Cao, Mingwei Zhong, Siyu Wang, Qibin Li, Wei Ma, Xiaodong Yan, Jing Wang, Yuan Zhao\",\"doi\":\"10.1021/acsabm.5c00533\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Persistent inflammation effects existed in the senescence microenvironment, and hydrogen (H<sub>2</sub>) was an antioxidant stress agent and could solve the aging and inflammation. In view of the issue of low solubility of H<sub>2</sub> and conversion efficiency of traditional hydrogen therapy, an in-site hydrogen production system (HPS) was designed by using liposome as a compartment, emodin as a photosensitizer, l-ascorbic acid-2-phosphate trisodium salt (AAP) as hydrogen sources, and Au NPs as photocatalysts. Different from the commonly used chlorophyll A, emodin with strong absorption in the wide range of 200-500 nm could absorb more photons to form electrons for the participation of H<sub>2</sub> generation. Emodin- and AAP-embedded HPS largely increased stability at 50 °C for 28 days. HPS facilitated the decrease of inflammatory factors of TNF-α, IL-6, and ROS in RAW264.7 cells, as well as the elimination of senescence-associated β-galactosidase, realizing convenient and efficient antifading responses. But strikingly, the constructed HPS can penetrate the pig skin in transdermal experiments and showed huge prospects for the application of antifading cosmetics.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":\" \",\"pages\":\"5205-5214\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-06-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1021/acsabm.5c00533\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsabm.5c00533","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
A Stable and Local H2 Nanogenerator for Antifading Responses.
Persistent inflammation effects existed in the senescence microenvironment, and hydrogen (H2) was an antioxidant stress agent and could solve the aging and inflammation. In view of the issue of low solubility of H2 and conversion efficiency of traditional hydrogen therapy, an in-site hydrogen production system (HPS) was designed by using liposome as a compartment, emodin as a photosensitizer, l-ascorbic acid-2-phosphate trisodium salt (AAP) as hydrogen sources, and Au NPs as photocatalysts. Different from the commonly used chlorophyll A, emodin with strong absorption in the wide range of 200-500 nm could absorb more photons to form electrons for the participation of H2 generation. Emodin- and AAP-embedded HPS largely increased stability at 50 °C for 28 days. HPS facilitated the decrease of inflammatory factors of TNF-α, IL-6, and ROS in RAW264.7 cells, as well as the elimination of senescence-associated β-galactosidase, realizing convenient and efficient antifading responses. But strikingly, the constructed HPS can penetrate the pig skin in transdermal experiments and showed huge prospects for the application of antifading cosmetics.
期刊介绍:
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.