封面：多肽药物开发中的科林斯环修饰-“科林斯”简史（ChemMedChem 10/2025）

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-05-20 DOI:10.1002/cmdc.202581001

Nancy Cham, Robert P. Doyle

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引用次数: 0

摘要

封面艺术展示了肽加冕肽管理，靶向递送和新结构的新途径。这些新多肽具有口服递送、改善蛋白酶稳定性、防止聚集和中枢神经系统与周围神经系统定位的变化的潜力。更多细节可以在10.1002/cmdc中找到。南希·查姆和罗伯特·p·多伊尔，202500129。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Front Cover: Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination” (ChemMedChem 10/2025)

The cover art shows the coronation of peptides crowning new routes to peptide administration, targeted delivery and novel structures. These new peptides show potential for oral delivery, improved protease stability, prevention of aggregation and changes to central nervous system versus peripheral nervous system localization. More details can be found in article 10.1002/cmdc.202500129 by Nancy Cham and Robert P. Doyle.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.