生物素化共聚物与钆离子络合活性靶向胶体载体的设计

IF 5.8 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nanoscale Pub Date : 2025-05-20 DOI:10.1039/d5nr00986c

Maksym Odnoroh, Franck Desmoulin, Olivier Coutelier, Carine Pestourie, Christophe Mingotaud, Mathias Destarac, Jean-Daniel Marty

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引用次数: 0

摘要

本研究提出了利用RAFT聚合物设计生物素功能化杂化多离子复合物（hpic）用于靶向MRI应用。合成的胶体载体与钆离子络合，具有高稳定性、弛豫性和生物素可及性。初步的体内研究证实了它们在改善MRI对比和药代动力学跟踪方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Design of Colloidal Vectors for Active Targeting via Complexation of Biotinylated Copolymers with Gadolinium Ions

This study presents the design of biotin-functionalized hybrid polyionic complexes (HPICs) using RAFT polymers for targeted MRI applications. The synthesized colloidal vectors, complexed with gadolinium ions, demonstrate high stability, relaxivity, and biotin accessibility for active targeting. Preliminary in vivo studies confirm their potential for improved MRI contrast and pharmacokinetic tracking.

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来源期刊

Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

12.10

自引率

3.00%

发文量

1628

审稿时长

1.6 months

期刊介绍： Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.