线粒体和光合疗法:重塑细胞代谢功能的关键策略

IF 6.1 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Muhammad Samee Mubarik, Zizhen Zhao, Mehdi Khoshnamvand, De‐Sheng Pei, Ailing Fu
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引用次数: 0

摘要

核外细胞器移植是细胞生物学和生物工程领域的一个新兴领域,通过在细胞间或物种间转移线粒体等细胞器,提供了创新的治疗可能性。在生物体中,线粒体和叶绿体与细胞内物质和能量的转化密切相关。线粒体移植治疗旨在重建患病或受损细胞的细胞代谢功能,在代谢性疾病的治疗中具有广泛的应用潜力。该疗法提供了一种独特的细胞修复技术,通过在细胞器水平上靶向能量产生,这将为动物细胞提供新的能量来源。目前,线粒体移植治疗已被应用于临床环境中作为一种新的方法来拯救患者,基于叶绿体的移植赋予动物细胞利用光能(光合动物细胞)。本文综述了线粒体和光合疗法在生物医学领域的研究进展及应用前景。核外移植技术将对生物治疗产生创新和深远的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitochondrial and photosynthetic therapy: A crucial strategy for remodeling cellular metabolic function
Extranuclear organelle transplantation, an emerging field in cell biology and bioengineering, presents innovative therapeutic possibilities by transferring organelles such as mitochondria between cells or across species. In living organisms, mitochondria and chloroplasts are closely related to converting substances and energy within cells. Transplantation therapy of mitochondria seeks to rebuild cell metabolic function in diseased or damaged cells and has broad application potential in treating metabolic diseases. The therapies provide a distinctive technology for cellular restoration by targeting energy generation at the organelle level, which will offer new energy resources for animal cells. At present, mitochondrial transplantation therapy has been applied as a novel approach to rescue patients in clinical settings, and chloroplast‐based transplantation endows animal cells to utilize light energy (photosynthetic animal cells). In this review, we discuss the exciting development and application prospects of mitochondrial and photosynthetic therapy in biomedicine. The technology of extranuclear transplantation would exert innovative and profound impacts on biological therapy.
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来源期刊
Bioengineering & Translational Medicine
Bioengineering & Translational Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
8.40
自引率
4.10%
发文量
150
审稿时长
12 weeks
期刊介绍: Bioengineering & Translational Medicine, an official, peer-reviewed online open-access journal of the American Institute of Chemical Engineers (AIChE) and the Society for Biological Engineering (SBE), focuses on how chemical and biological engineering approaches drive innovative technologies and solutions that impact clinical practice and commercial healthcare products.
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