包封法提高Cu(I)-NHC配合物在生物培养基中的CuAAC效率

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-05-20 DOI:10.1039/d5cc01891a

A.P. Prakasham, Harshit Singh, Anja Palmans

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引用次数: 0

摘要

一种新型的[(NHC)2Cu]Br （Cu(I)-NHC）配合物在有机溶剂、水、缓冲液甚至复杂的生物介质中促进CuAAC反应，收率高。铜催化剂在两亲性聚合物中的包封增强了其在复杂介质中的性能，增加了催化剂在谷胱甘肽存在下的稳定性，并降低了HeLa细胞的细胞毒性。

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Enhancing the CuAAC efficiency of a Cu(I)-NHC complex in biological media by encapsulation

A novel [(NHC)2Cu]Br (Cu(I)-NHC) complex promotes CuAAC reactions in organic solvents, water, buffers and even in complex biological media in good yields. Encapsulation of the Cu catalyst in an amphiphilic polymer enhances its performance in complex media, increases catalyst stability in presence of glutathione and reduces cytotoxicity in HeLa cells.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.