{"title":"高强度激光治疗中脉冲和连续波模式的比较分析:对深层组织治疗的启示。","authors":"Chironjeet Chaki, Luis De Taboada, Kwong Ming Tse","doi":"10.1002/jbio.202400164","DOIUrl":null,"url":null,"abstract":"<p>High-intensity laser at a wavelength of 1064 nm has gained significant attention in the field of therapeutic applications due to its potential to penetrate deeper. Continuous wave laser therapy, although effective, poses a challenge of elevated skin temperature. This study endeavors to explore the transition from continuous to pulsed laser, aiming to enhance light fluence in deep tissue while mitigating skin temperature rise. Investigating continuous versus pulsed wave in transdermal deep tissue light therapy, this research utilizes a high-intensity laser at 1064 nm to optimize fluence in deep muscle tissue of the human knee, minimizing absorption-driven skin temperature rise. Simulated parameters, including peak power (60 W), pulse width (2 ms), duty cycle (10%), frequency (50 Hz), as well as beam size of 20 mm, indicate that pulsed wave irradiation after 300 s achieved the lowest skin surface temperature (42.5°C) and the highest fluence (approximately 4.2 J/cm<sup>2</sup>).</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 7","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbio.202400164","citationCount":"0","resultStr":"{\"title\":\"Comparative Analysis of Pulsed and Continuous Wave Modes in High-Intensity Laser Light Therapy: Implications for Deep Tissue Treatment\",\"authors\":\"Chironjeet Chaki, Luis De Taboada, Kwong Ming Tse\",\"doi\":\"10.1002/jbio.202400164\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>High-intensity laser at a wavelength of 1064 nm has gained significant attention in the field of therapeutic applications due to its potential to penetrate deeper. Continuous wave laser therapy, although effective, poses a challenge of elevated skin temperature. This study endeavors to explore the transition from continuous to pulsed laser, aiming to enhance light fluence in deep tissue while mitigating skin temperature rise. Investigating continuous versus pulsed wave in transdermal deep tissue light therapy, this research utilizes a high-intensity laser at 1064 nm to optimize fluence in deep muscle tissue of the human knee, minimizing absorption-driven skin temperature rise. Simulated parameters, including peak power (60 W), pulse width (2 ms), duty cycle (10%), frequency (50 Hz), as well as beam size of 20 mm, indicate that pulsed wave irradiation after 300 s achieved the lowest skin surface temperature (42.5°C) and the highest fluence (approximately 4.2 J/cm<sup>2</sup>).</p>\",\"PeriodicalId\":184,\"journal\":{\"name\":\"Journal of Biophotonics\",\"volume\":\"18 7\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbio.202400164\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biophotonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jbio.202400164\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biophotonics","FirstCategoryId":"101","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbio.202400164","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Comparative Analysis of Pulsed and Continuous Wave Modes in High-Intensity Laser Light Therapy: Implications for Deep Tissue Treatment
High-intensity laser at a wavelength of 1064 nm has gained significant attention in the field of therapeutic applications due to its potential to penetrate deeper. Continuous wave laser therapy, although effective, poses a challenge of elevated skin temperature. This study endeavors to explore the transition from continuous to pulsed laser, aiming to enhance light fluence in deep tissue while mitigating skin temperature rise. Investigating continuous versus pulsed wave in transdermal deep tissue light therapy, this research utilizes a high-intensity laser at 1064 nm to optimize fluence in deep muscle tissue of the human knee, minimizing absorption-driven skin temperature rise. Simulated parameters, including peak power (60 W), pulse width (2 ms), duty cycle (10%), frequency (50 Hz), as well as beam size of 20 mm, indicate that pulsed wave irradiation after 300 s achieved the lowest skin surface temperature (42.5°C) and the highest fluence (approximately 4.2 J/cm2).
期刊介绍:
The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.