微流控系统中多参数血脑屏障三维检测模型的研究进展。

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Chiara Boncristiani, Alessia Di Gilio, Federica De Castro, Alessandra Nardini, Jolanda Palmisani, Rebeca Martínez Vázquez, Gianluigi de Gennaro, Francesco Paolo Fanizzi, Giuseppe Ciccarella and Viviana Vergaro
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引用次数: 0

摘要

微流控技术已成为血脑屏障(BBB)建模研究生理或病理条件的一项有价值的技术,在神经科学和制药研究中发挥着重要作用。在这里,我们讨论了基于微流体系统的最新进展和潜在应用,因为这些模型不同于2D, Transwell和器官芯片,可以准确地模拟血脑屏障的生理特征。本文还从内部和分泌代谢物的角度,对化学传感器的集成进行了展望,包括电化学传感器、使用MIPs的化学传感器和代谢组学检测,以评估BBB模型。这种整合有助于获得改善脑血管介入治疗的新见解,并为临床实践发现新的诊断工具。最后,讨论并提出了在神经科学研究中推进基于微流体的脑屏障系统的挑战和未来前景,特别是在多学科基础研究和更广泛疾病治疗的治疗应用方面的新机遇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent advances in 3D models for multiparametric blood–brain barrier detection in microfluidic systems

Recent advances in 3D models for multiparametric blood–brain barrier detection in microfluidic systems

Microfluidics has emerged as a valuable technology for modeling the blood–brain barrier (BBB) to study physiological or pathological conditions and plays an important role in neuroscience and pharmaceutical research. Here we discuss the recent advances and the potential application of microfluidic-based systems, because these models, unlike 2D, Transwell and organ-on-chip, accurately mimic the physiological characteristics of the BBB. This review also provides outlooks on the integration of chemical sensors for evaluating BBB models through electrochemical sensors, chemical sensors using MIPs and metabolomic detection, in terms of internal and secreted metabolites. This integration is useful to gain new insights for improving cerebral vascular interventional therapies and discovering new diagnostic tools for clinical practice. Finally, the challenges and future prospects for advancing microfluidics-based BBB systems in neuroscience research are discussed and proposed, particularly regarding new opportunities in multi-disciplinary fundamental research and therapeutic applications for a broader range of disease treatments.

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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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