神经退行性疾病视网膜成像生物标志物的系统评价和网络meta分析：与大脑变化的相关性。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-05-16 DOI:10.1016/j.pdpdt.2025.104632

Farzaneh Nikparast , Zohreh Ganji , Hoda Zare , Nooshin Akbari-Sharak

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引用次数: 0

摘要

视网膜和大脑具有相同的胚胎起源和神经组成。两者在神经退行性疾病（NDs）中都经历了结构、血管和生理上的改变。该系统和网络荟萃分析（NMA）旨在识别NDs谱系中的视网膜-脑生物标志物。方法：我们使用随机效应模型进行NMA评估阿尔茨海默病（AD）和轻度认知障碍（MCI）视网膜层厚度的变化。研究人员分析了2016年至2023年间发表的225例AD患者、97例MCI患者和345例认知正常（CN）患者的数据。脑成像结果也进行了评估以进行比较。结果：与对照组相比，MCI组下、上乳头周围视网膜神经纤维层（pRNFL）和黄斑内厚度明显变薄。具体来说,减少被观察到在右眼劣质pRNFL (SMD = -21.5306),右眼优越pRNFL (SMD = -11.5011),左眼下pRNFL (SMD = -27.6244),左眼优越pRNFL (SMD = -9.8137),和内心的黄斑厚度(SMD = -4.8791)。AD与MCI比较，右眼鼻pRNFL （SMD = 5.95）、左眼上pRNFL （SMD = -9.1786）、外黄斑厚度（SMD = -4.1046）明显变薄。AD和CN在大多数视网膜区域无显著差异。结论：上、下pRNFL及黄斑内层变薄可能是MCI的早期生物标志物。在阿尔茨海默病中，视网膜层变薄伴随着海马、内嗅皮层和颞叶萎缩，黄斑体积（EZ-RPE）与总脑容量相关。

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Systematic review and network meta-analysis of retinal imaging biomarkers in neurodegenerative diseases: Correlation with brain changes

Introduction

The retina and brain share a common embryonic origin and neural composition. Both undergo structural, vascular, and physiological changes in neurodegenerative diseases (NDs). This Systematic and network meta-analysis (NMA) aims to identify retinal-brain biomarkers across the spectrum of NDs.

Methods

We conducted an NMA using random-effects models to assess retinal layer thickness changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Data from 225 AD patients, 97 MCI patients, and 345 cognitively normal (CN) individuals, published between 2016 and 2023, were analyzed. Brain imaging findings were also evaluated for comparison.

Results

Compared to controls, the MCI group exhibited significant thinning in the inferior and superior peripapillary retinal nerve fiber layer (pRNFL) and inner macular thickness. Specifically, reductions were observed in Right Eye Inferior pRNFL (SMD = -21.5306), Right Eye Superior pRNFL (SMD = -11.5011), Left Eye Inferior pRNFL (SMD = -27.6244), Left Eye Superior pRNFL (SMD = -9.8137), and Inner Macular Thickness (SMD = -4.8791). When comparing AD to MCI, Right Eye Nasal pRNFL (SMD = 5.95), Left Eye Superior pRNFL (SMD = -9.1786), and Outer Macular Thickness (SMD = -4.1046) were significantly thinner in AD. No significant differences were found between AD and CN in most retinal regions.

Conclusion

Thinning of the superior and inferior pRNFL and inner macular layer may serve as early biomarkers of MCI. In AD, retinal layer thinning is accompanied by hippocampal, entorhinal cortex, and temporal lobe atrophy, with macular volume (EZ-RPE) correlating with total brain volume.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.