固体口服药物暴露于模拟舱内空间辐射的长期稳定性。

IF 4.4 1区 物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES
Ianik Plante, Vernie Daniels, Millennia Young, Ramona Gaza, Honglu Wu, John F Reichard
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引用次数: 0

摘要

为空间任务带来的医药产品必须在整个任务期间保持有效和安全。美国宇航局之前的实验表明,在长时间的太空任务中,辐射暴露可能会威胁到药物的稳定性。探索医疗能力(ExMC)单元通过在美国宇航局空间辐射实验室将四种药物暴露于模拟银河宇宙辐射(GCRSim),然后进行三年的储存期,评估了这种可能性。使用固体口服药物对乙酰氨基酚、阿莫西林、布洛芬和异丙嗪。每种药物的相同批次被分配到四个实验组:未辐照的约翰逊航天中心对照组、未辐照的旅行对照组、辐照组I (GRSim, 0.5 Gy)和辐照组II (GCRSim, 1.0 Gy)。辐照后2个月、18个月和34个月对药品的活性成分、降解杂质和溶出度进行评估。所有样品都显示出类似的降解,表明GCR暴露不会促进药物的降解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The long-term stability of solid-state oral pharmaceuticals exposed to simulated intravehicular space radiation.

Pharmaceutical products brought for space missions must remain effective and safe throughout the mission. Previous NASA experiments suggest that radiation exposure could threaten drug stability during long-duration space missions. The Exploration Medical Capability (ExMC) Element has evaluated this possibility by exposing four medications to simulated Galactic Cosmic Radiation (GCRSim) at the NASA Space Radiation Laboratory followed by a three-year storage period. The solid oral drug products Acetaminophen, Amoxicillin, Ibuprofen, and Promethazine were used. Identical lots of each medication were assigned to four experimental groups: the non-irradiated Johnson Space Center control group, the non-irradiated traveling control group, the irradiation group I (GRSim, 0.5 Gy), and the irradiation group II (GCRSim, 1.0 Gy). Drug products were assessed for active pharmaceutical ingredient, degradation impurities, and dissolution 2, 18, and 34 months after irradiation. All samples show comparable degradation, revealing that GCR exposure does not facilitate the degradation of the drugs.

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来源期刊
npj Microgravity
npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)
CiteScore
7.30
自引率
7.80%
发文量
50
审稿时长
9 weeks
期刊介绍: A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.
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