{"title":"尿路病原体的抗生素耐药模式：来自尼泊尔三级医疗机构的见解。","authors":"Rahi Bikram Thapa, Sabin Shrestha, Pharsuram Adhikari, Rajeev Shrestha","doi":"10.1177/20499361251339383","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance in uropathogens is increasing globally, particularly in resource-limited settings such as Nepal, limiting treatment options.</p><p><strong>Objectives: </strong>This study aimed to evaluate the antimicrobial resistance patterns of uropathogens isolated from patients with urinary tract infections (UTIs) in a tertiary care hospital in central Nepal.</p><p><strong>Design: </strong>This study utilized a retrospective study design.</p><p><strong>Methods: </strong>We retrospectively observed medical records from August 2023 to February 2024 at Manmohan Memorial Teaching Hospital in Nepal, focusing on patients with significant bacterial growth in urine samples and antibiotic sensitivity analysis for resistance trends.</p><p><strong>Results: </strong><i>Escherichia coli</i> (<i>E. coli</i>) (64.7%) and <i>Klebsiella pneumoniae</i> (<i>K. pneumoniae</i>) (15.0%) were the most common uropathogens. Both showed the highest resistance to amoxicillin (>95%), while <i>E. coli</i> demonstrated the lowest resistance to gentamicin (7.4%) and nitrofurantoin (12.2%). <i>Klebsiella pneumoniae</i> also showed low resistance to gentamicin (12.0%) but higher resistance to nitrofurantoin (64.0%).</p><p><strong>Conclusion: </strong>Empirical therapy, including nitrofurantoin and aminoglycosides, is a viable option for combating antimicrobial resistance in Nepal, necessitating region-specific surveillance and multicentre studies.</p>","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"12 ","pages":"20499361251339383"},"PeriodicalIF":3.8000,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084692/pdf/","citationCount":"0","resultStr":"{\"title\":\"Antibiotic resistance patterns in uropathogens: insights from a Nepalese tertiary care setting.\",\"authors\":\"Rahi Bikram Thapa, Sabin Shrestha, Pharsuram Adhikari, Rajeev Shrestha\",\"doi\":\"10.1177/20499361251339383\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Antimicrobial resistance in uropathogens is increasing globally, particularly in resource-limited settings such as Nepal, limiting treatment options.</p><p><strong>Objectives: </strong>This study aimed to evaluate the antimicrobial resistance patterns of uropathogens isolated from patients with urinary tract infections (UTIs) in a tertiary care hospital in central Nepal.</p><p><strong>Design: </strong>This study utilized a retrospective study design.</p><p><strong>Methods: </strong>We retrospectively observed medical records from August 2023 to February 2024 at Manmohan Memorial Teaching Hospital in Nepal, focusing on patients with significant bacterial growth in urine samples and antibiotic sensitivity analysis for resistance trends.</p><p><strong>Results: </strong><i>Escherichia coli</i> (<i>E. coli</i>) (64.7%) and <i>Klebsiella pneumoniae</i> (<i>K. pneumoniae</i>) (15.0%) were the most common uropathogens. Both showed the highest resistance to amoxicillin (>95%), while <i>E. coli</i> demonstrated the lowest resistance to gentamicin (7.4%) and nitrofurantoin (12.2%). <i>Klebsiella pneumoniae</i> also showed low resistance to gentamicin (12.0%) but higher resistance to nitrofurantoin (64.0%).</p><p><strong>Conclusion: </strong>Empirical therapy, including nitrofurantoin and aminoglycosides, is a viable option for combating antimicrobial resistance in Nepal, necessitating region-specific surveillance and multicentre studies.</p>\",\"PeriodicalId\":46154,\"journal\":{\"name\":\"Therapeutic Advances in Infectious Disease\",\"volume\":\"12 \",\"pages\":\"20499361251339383\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-05-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084692/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic Advances in Infectious Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/20499361251339383\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Infectious Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20499361251339383","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Antibiotic resistance patterns in uropathogens: insights from a Nepalese tertiary care setting.
Background: Antimicrobial resistance in uropathogens is increasing globally, particularly in resource-limited settings such as Nepal, limiting treatment options.
Objectives: This study aimed to evaluate the antimicrobial resistance patterns of uropathogens isolated from patients with urinary tract infections (UTIs) in a tertiary care hospital in central Nepal.
Design: This study utilized a retrospective study design.
Methods: We retrospectively observed medical records from August 2023 to February 2024 at Manmohan Memorial Teaching Hospital in Nepal, focusing on patients with significant bacterial growth in urine samples and antibiotic sensitivity analysis for resistance trends.
Results: Escherichia coli (E. coli) (64.7%) and Klebsiella pneumoniae (K. pneumoniae) (15.0%) were the most common uropathogens. Both showed the highest resistance to amoxicillin (>95%), while E. coli demonstrated the lowest resistance to gentamicin (7.4%) and nitrofurantoin (12.2%). Klebsiella pneumoniae also showed low resistance to gentamicin (12.0%) but higher resistance to nitrofurantoin (64.0%).
Conclusion: Empirical therapy, including nitrofurantoin and aminoglycosides, is a viable option for combating antimicrobial resistance in Nepal, necessitating region-specific surveillance and multicentre studies.
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